IRF9

Gene Symbol	IRF9
Entrez Gene	10379
Alt Symbol	IRF-9, ISGF3, ISGF3G, p48
Species	Human
Gene Type	protein-coding
Description	interferon regulatory factor 9
Other Description	IFN-alpha-responsive transcription factor subunit|ISGF-3 gamma|ISGF3 p48 subunit|interferon-stimulated gene factor 3 gamma|interferon-stimulated transcription factor 3, gamma (48kD)|interferon-stimulated transcription factor 3, gamma 48kDa|transcriptional regulator ISGF3 subunit gamma
Swissprots	D3DS61 Q00978
Accessions	EAW66092 EAW66093 EAW66094 Q00978 AK295467 BAG58398 AK308347 BC035716 AAH35716 BI497082 BI919023 EU446692 ABZ92221 M87503 AAA58687 U92994 NM_006084 NP_006075
Function	Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11846981}. Nucleus {ECO:0000269|PubMed:11846981}. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.
Top Pathways	Jak-STAT signaling pathway, Hepatitis C, Osteoclast differentiation, Measles, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Interferon regulatory factor 9 full length protein - ab132260 from Abcam Category Protein Source Wheat germ Species Human

Human Interferon regulatory factor 9 protein fragment - ab126019 from Abcam Category Protein Source E. coli Species Human

ISGF3 / IRF9 Blocking Peptide - LS-E1280 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human IRF9 Protein - H00010379-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

IRF9-Antibody-N-term-Blocking-peptide - BP11875a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IRF9 / ISGF3G - H00010379-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

IRF9 / ISGF3G - H00010379-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

IRF9 fusion protein - ag5943 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

IRF9 fusion protein - Ag5365 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Interferon Regulatory Factor 9 (IRF9) - RPH780Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Interferon Regulatory Factor 9 (IRF9) - RPH780Hu01 from Cloud-clone Category Protein Source E.coli Species Human

IRF9 / ISGF3G - TP307768 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

p48 protein (P48), Recombinant Protein - MBS1065561 from MyBioSource Category Protein Prices $1,185.00, $1,185.00, $1,405.00, $1,405.00, $1,905.00, $1,905.00, $2,370.00, $2,370.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

IRF9 Recombinant Protein Antigen - NBP1-81577PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

IRF9 Peptide, Human - M34GP07745H from Creative Peptides Category Peptide Source Synthetic. Species Human

Search more