TBK1

Gene Symbol	TBK1
Entrez Gene	29110
Alt Symbol	NAK, T2K
Species	Human
Gene Type	protein-coding
Description	TANK-binding kinase 1
Other Description	NF-kB-activating kinase|NF-kappa-B-activating kinase|serine/threonine-protein kinase TBK1
Swissprots	Q8IYV3 A8K4S4 Q9NUJ5 Q9UHD2
Accessions	EAW97133 Q9UHD2 AA970899 AF174536 AAF69106 AF191838 AAF05989 AK002192 BAA92129 AK291039 BAF83728 AK303683 BAG64676 AW275367 BC034950 AAH34950 DA788357 XM_005268809 XP_005268866 XM_005268810 XP_005268867 XR_944524 XR_944525 NM_013254 NP_037386
Function	Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferatio
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:21813773}. Note=Upon mitogen stimulation or triggering of the immune system, TBK1 is recruited to the exocyst by EXOC2.
Tissue Specificity	Ubiquitous with higher expression in testis. Expressed in the ganglion cells, nerve fiber layer and microvasculature of the retina. {ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:21447600}.
Top Pathways	Hepatitis C, Toll-like receptor signaling pathway, Measles, Influenza A, Cytosolic DNA-sensing pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NAK / TBK1 ELISA Kit (Sandwich ELISA) - LS-F8866 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.124 ng/ml Range 0.313-20 ng/ml

Mouse NAK / TBK1 ELISA Kit (Sandwich ELISA) - LS-F12700 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 Range 0.313-20 ng/ml

Serine/threonine-protein kinase TBK1, TBK1, Human, ELISA Kit - E13052h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

TANK Binding Kinase 1 (TBK1), Human, ELISA Kit - SEH061Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.112ng/mL Range 0.312-20ng/mL

TANK Binding Kinase 1 (TBK1), ELISA Kit - MBS2020540 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.124ng/mL. Range 0.313-20ng/mL

TANK-binding kinase 1, ELISA Kit - MBS9330803 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for TANK Binding Kinase 1 (TBK1) - SEH061Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.124ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for TANK Binding Kinase 1 (TBK1) - SEH061Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.124ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human NAK / TBK1 ELISA Kit (Sandwich ELISA) - LS-F16825 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.313-20 ng/ml

TANK Binding Kinase 1 (TBK1), Human, ELISA Kit - DL-TBK1-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Human TBK1 ELISA Kit - abx572986 from Abbexa Category ELISA Kit Sensitivity 0.112 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human, Mouse and Rat Phospho-TBK1 (S172) ELISA - PEL-TBK1-S172-1 from RayBiotech Category ELISA Kit Prices $481.00, $865.80, $1,924.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human, Mouse and Rat Phospho-TBK1 (S172) and Total TBK1 ELISA - PEL-TBK1-S172-T-1 from RayBiotech Category ELISA Kit Prices $525.00, $945.00, $2,100.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human/Mouse/Rat TBK1 (Phospho-Ser172) ELISA Kit - orb385002 from Biorbyt Category ELISA Kit Prices $1,122.00, $1,938.00, $4,182.00 Sizes 96 assays, 192 assays, 480 assays

Human TBK1 ELISA Kit - E034833 from Biobool Category ELISA Kit

Human Serine/threonine-protein kinase TBK1 ELISA Kit - EK3167 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Range 0.156-10 ng/mL

TBK1 ELISA Kit (Human) (OKCD02920) - OKCD02920 from Aviva Systems Biology Category ELISA Kit Prices $545.00 Sizes 20 ng Sensitivity 0.124 ng/mL Range 0.312-20 ng/mL

Serine/threonine-protein kinase TBK1, ELISA Kit - MBS9427001 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Range 0.156-10 ng/mL

Serine/threonine-protein kinase TBK1, ELISA Kit - MBS2887613 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.15ng/mL -10.0ng/mL.

TANK Binding Kinase 1 (TBK1), ELISA Kit - MBS454044 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.112ng/mL Range 0.312-20ng/mL

Serine/threonine-protein kinase TBK1, ELISA Kit - MBS761047 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 18.75pg/ml Range 31.2-2000pg/ml

TANK Binding Kinase 1, ELISA Kit - MBS2533500 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.375ng/mL Range 0.625-40ng/mL

TANK Binding Kinase 1 (TBK1), ELISA Kit - MBS9371349 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

TBK1 ELISA Kit (Human) (OKEH07181) - OKEH07181 from Aviva Systems Biology Category ELISA Kit Sensitivity 0.156 ng/mL Range 0.156 - 10 ng/mL

Mouse NAK / TBK1 ELISA Kit (Sandwich ELISA) - LS-F35939 from LifeSpan Bioscience Category ELISA Kit Sensitivity 18.75 Range 0.313-20 ng/ml

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