TBK1

Gene Symbol	TBK1
Entrez Gene	29110
Alt Symbol	NAK, T2K
Species	Human
Gene Type	protein-coding
Description	TANK-binding kinase 1
Other Description	NF-kB-activating kinase|NF-kappa-B-activating kinase|serine/threonine-protein kinase TBK1
Swissprots	Q8IYV3 A8K4S4 Q9NUJ5 Q9UHD2
Accessions	EAW97133 Q9UHD2 AA970899 AF174536 AAF69106 AF191838 AAF05989 AK002192 BAA92129 AK291039 BAF83728 AK303683 BAG64676 AW275367 BC034950 AAH34950 DA788357 XM_005268809 XP_005268866 XM_005268810 XP_005268867 XR_944524 XR_944525 NM_013254 NP_037386
Function	Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferatio
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:21813773}. Note=Upon mitogen stimulation or triggering of the immune system, TBK1 is recruited to the exocyst by EXOC2.
Tissue Specificity	Ubiquitous with higher expression in testis. Expressed in the ganglion cells, nerve fiber layer and microvasculature of the retina. {ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:21447600}.
Top Pathways	Hepatitis C, Toll-like receptor signaling pathway, Measles, Influenza A, Cytosolic DNA-sensing pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human NAK full length protein - ab85276 from Abcam Category Protein Prices $302.00, $352.00, $1,845.00 Sizes 5 µg, 10 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Human NAK full length protein - ab162224 from Abcam Category Protein Source Wheat germ Species Human

NAK peptide - ab6236 from Abcam Category Peptide

NAK peptide - ab86401 from Abcam Category Peptide

NAK / TBK1 Antibody Blocking Peptide - LS-E4931 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NAK / TBK1 Blocking Peptide - LS-E7445 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NAK / TBK1 Antibody Blocking Peptide - LS-E29952 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NAK / TBK1 Antibody Blocking Peptide - LS-E9348 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NAK / TBK1 Antibody Blocking Peptide - LS-E19805 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NAK / TBK1 Antibody Blocking Peptide - LS-E19806 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TBK1 Protein - H00029110-P01 from Novus Biologicals Category Protein Prices $250.00, $369.00 Sizes 2 µg, 10 µg Source Wheat Germ Species Human

Recombinant Human TBK1 Protein - H00029110-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TBK1 Recombinant Protein - P4782 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

TBK1 Peptide - NBP1-76783PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

Phospho-TBKS172-Antibody-Blocking-peptide - BP3627a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

TBK1-Antibody-S172-Blocking-peptide - BP7887a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NAK peptide - GTX26236 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

TBK1 Blocking Peptide - 33R-2352 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TBK1 Blocking Peptide - 33R-7524 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TBK1 Blocking Peptide - abx161223 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey, Pig

NAK Peptide - AC21-2857-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TBK1 - H00029110-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

TBK1 - H00029110-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

TBK1 - H00029110-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TBK1 - H00029110-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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