TBK1

Gene Symbol	TBK1
Entrez Gene	29110
Alt Symbol	NAK, T2K
Species	Human
Gene Type	protein-coding
Description	TANK-binding kinase 1
Other Description	NF-kB-activating kinase|NF-kappa-B-activating kinase|serine/threonine-protein kinase TBK1
Swissprots	Q8IYV3 A8K4S4 Q9NUJ5 Q9UHD2
Accessions	EAW97133 Q9UHD2 AA970899 AF174536 AAF69106 AF191838 AAF05989 AK002192 BAA92129 AK291039 BAF83728 AK303683 BAG64676 AW275367 BC034950 AAH34950 DA788357 XM_005268809 XP_005268866 XM_005268810 XP_005268867 XR_944524 XR_944525 NM_013254 NP_037386
Function	Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferatio
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:21813773}. Note=Upon mitogen stimulation or triggering of the immune system, TBK1 is recruited to the exocyst by EXOC2.
Tissue Specificity	Ubiquitous with higher expression in testis. Expressed in the ganglion cells, nerve fiber layer and microvasculature of the retina. {ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:21447600}.
Top Pathways	Hepatitis C, Toll-like receptor signaling pathway, Measles, Influenza A, Cytosolic DNA-sensing pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TBK1 - MBS1276893 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC034950

Human TBK1 ORF Clone(NM_013254.3) - CDCL177987 from Creative Biomart Species Human Accession NM_013254.3

human TBK1 ORF clone - CDCH088726 from Creative Biomart Species Human Accession NM_013254

human TBK1 ORF clone - CDCH088727 from Creative Biomart Species Human Accession NM_013254

Human TBK1 Gene ORF cDNA clone in cloning vector - HG11023-M from Sino Biological Species Human

Human TBK1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11023-NF from Sino Biological Species Human

Human TBK1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11023-NM from Sino Biological Species Human

Human TBK1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11023-CF from Sino Biological Species Human

Human TBK1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11023-ACR from Sino Biological Species Human

Human TBK1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11023-CM from Sino Biological Species Human

Human TBK1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11023-ANR from Sino Biological Species Human

Human TBK1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11023-CY from Sino Biological Species Human

Human TBK1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11023-ANG from Sino Biological Species Human

Human TBK1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11023-NY from Sino Biological Species Human

Human TBK1 Gene ORF cDNA clone expression plasmid, N-His tag - HG11023-NH from Sino Biological Species Human

Human TBK1 Gene ORF cDNA clone expression plasmid - HG11023-UT from Sino Biological Species Human

Human TBK1 Gene ORF cDNA clone expression plasmid, C-His tag - HG11023-CH from Sino Biological Species Human

Human TBK1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11023-ACG from Sino Biological Species Human

Human TBK1 ORF Clone (BC034950) - CDCS413374 from Creative biogene Species Human Accession Q9UHD2

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