RSPO3

Gene Symbol	RSPO3
Entrez Gene	84870
Alt Symbol	CRISTIN1, PWTSR, THSD2
Species	Human
Gene Type	protein-coding
Description	R-spondin 3
Other Description	R-spondin 3 homolog|R-spondin-3|protein with TSP type-1 repeat|roof plate-specific spondin-3|thrombospondin type-1 domain-containing protein 2|thrombospondin, type I, domain containing 2
Swissprots	Q96K87 Q5VTV4 B2RC27 Q9BXY4
Accessions	EAW48114 EAW48115 EAW48116 Q9BXY4 AA568446 AF086298 AF251057 AAK34947 AI095468 AK314912 BAG37424 BC022367 AAH22367 DQ891407 ABM82333 DQ894583 ABM85509 NM_032784 NP_116173
Function	Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. {ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22615920}.
Subcellular Location	Secreted {ECO:0000250}.
Tissue Specificity	Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node. {ECO:0000269|PubMed:12463421}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RSPO3 ELISA Kit (Sandwich ELISA) - LS-F7210 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 0.118 ng/ml Range 0.313-20 ng/ml

Human R-Spondin 3 DuoSet ELISA - DY3500 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 15.60 - 1,000 pg/mL

R-Spondin 3 (RSPO3), Human, ELISA Kit - SEM173Hu from ARP American Research Products Category ELISA Kit Prices $790.00 Sizes 96 t Sensitivity 0.116ng/mL Range 0.312-20ng/mL

R-Spondin 3, ELISA Kit - MBS083786 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

R-Spondin 3, ELISA Kit - MBS066144 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

R-Spondin 3, ELISA Kit - MBS071278 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

R-Spondin 3, ELISA Kit - MBS086939 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

R-Spondin 3, ELISA Kit - MBS100290 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

R-Spondin 3, ELISA Kit - MBS061684 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

R-Spondin 3, ELISA Kit - MBS070135 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

R-Spondin 3 (RSPO3), ELISA Kit - MBS2023893 from MyBioSource Category ELISA Kit Prices $410.00, $610.00, $830.00, $3,420.00, $6,200.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.118ng/mL. Range 0.313-20ng/mL

ELISA Kit for R-Spondin 3 (RSPO3) - SEM173Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.118ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for R-Spondin 3 (RSPO3) - SEM173Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.118ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human R-Spondin 3 (RSPO3) ELISA Kit - EKU07147 from Biomatik Category ELISA Kit Prices $809.00, $3,557.00, $6,468.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.118 ng/mL Range 0.312-20 ng/mL

Human R-Spondin 3 ELISA Kit - abx152988 from Abbexa Category ELISA Kit Sensitivity 0.128 ng/ml Range 0.313 ng/ml - 20 ng/ml

Mouse R-Spondin 3 DuoSet ELISA - DY4120-05 from R&D Systems Category ELISA Kit Prices $299.00 Sizes 1 kit (for 5 Plates) Range 9.38 - 600 pg/mL

R-Spondin 3 (RSPO3), Human, ELISA Kit - DL-RSPO3-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Human R-Spondin-3 ELISA Kit - orb371787 from Biorbyt Category ELISA Kit Prices $612.00 Sizes 96 well Sensitivity <10pg/ml Range 15.6pg/ml-1000pg/ml

Human RSPO3 ELISA Kit - abx572517 from Abbexa Category ELISA Kit Sensitivity 0.116 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human R-Spondin-3 PicoKine™ ELISA Kit EK1512 - EK1512 from Boster Bio Category ELISA Kit Prices $369.00 Sizes 1 kit Sensitivity <10pg/ml Range 15.6pg/ml-1000pg/ml *This assay range is determined using common samples. For samples with low target protein concentrations, users can adjust the standard curve to extend the lower limit of assay range.

Human RSPO3 ELISA Kit - CEK1887 from Cohesion Biosciences Category ELISA Kit Prices $380.00 Sizes 96 t Sensitivity 10 pg/ml Range 15.6 pg/ml - 1000 pg/ml

Custom Human R-Spondin 3 ELISA - ELH-RSPON3-1 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human RSPO3 ELISA Kit - orb385335 from Biorbyt Category ELISA Kit Prices $536.00 Sizes 96 test Sensitivity 10 pg/ml Range 15.6 pg/ml-1000 pg/ml

Human RSPO3 ELISA Kit - E032616 from Biobool Category ELISA Kit Sensitivity Typically less than 0.118ng/mL.

RSPO3 ELISA Kit (Human) (OKCD01079) - OKCD01079 from Aviva Systems Biology Category ELISA Kit Prices $585.00 Sizes 96 wells Sensitivity < 0.118 ng/mL Range 0.312-20 ng/mL

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