RSPO3

Gene Symbol RSPO3
Entrez Gene 84870
Alt Symbol CRISTIN1, PWTSR, THSD2
Species Human
Gene Type protein-coding
Description R-spondin 3
Other Description R-spondin 3 homolog|R-spondin-3|protein with TSP type-1 repeat|roof plate-specific spondin-3|thrombospondin type-1 domain-containing protein 2|thrombospondin, type I, domain containing 2
Swissprots Q96K87 Q5VTV4 B2RC27 Q9BXY4
Accessions EAW48114 EAW48115 EAW48116 Q9BXY4 AA568446 AF086298 AF251057 AAK34947 AI095468 AK314912 BAG37424 BC022367 AAH22367 DQ891407 ABM82333 DQ894583 ABM85509 NM_032784 NP_116173
Function Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. {ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22615920}.
Subcellular Location Secreted {ECO:0000250}.
Tissue Specificity Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node. {ECO:0000269|PubMed:12463421}.

R-Spondin3 (G-14) - sc-107984 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

R-Spondin3 (K-12) - sc-107985 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-RSPO3 antibody - ab109808 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-RSPO3 antibody (ab109808) at 0.3 µg/ml + Human skeletal muscle lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-RSPO3 antibody - C-terminal - ab171010 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-RSPO3 antibody - C-terminal (ab171010) at 1 µg/ml + HT1080 whole cell lysate at 10 µg

Anti-RSPO3 Antibody (clone 400404) - LS-C38971 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 400404

Anti-RSPO3 Antibody (aa22-272) - LS-C184886 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-RSPO3 Antibody (aa22-272, clone 4G10) - LS-C339384 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4G10
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RSPO3 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RSPO3 (1:500).

Anti-RSPO3 Antibody (aa181-193) - LS-C139710 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
RSPO3 antibody (0.3 ug/ml) staining of Human Skeletal Muscle lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-RSPO3 Antibody (aa202-251) - LS-C170341 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-RSPO3 Antibody (C-Terminus) - LS-C336277 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunocytochemistry of RSPO3 in 293 cells with RSPO3 antibody at 5 ug/mL.

Anti-RSPO3 Antibody (aa22-272, clone 3A9) - LS-C339260 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3A9
IHC of paraffin-embedded Carcinoma of Human liver tissue using anti-RSPO3 mouse monoclonal antibody. (heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-RSPO3 Antibody (aa22-272, clone 3D5) - LS-C339258 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3D5
IHC of paraffin-embedded Human thyroid tissue using anti-RSPO3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

R-Spondin 3 Antibody (400403) - MAB41201 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Rat
Clonality Monoclonal
Clone 400403

R-Spondin 3 Antibody (400404) - MAB4120 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Rat
Clonality Monoclonal
Clone 400404

R-Spondin 3 Antibody [Unconjugated] - AF3500 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal

R-Spondin 3 Antibody [Unconjugated] - AF35001 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal

R-Spondin 3 Antibody - NBP1-68868 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

R-Spondin 3 Antibody - NBP1-82234 from Novus Biologicals

Prices $129.00, $419.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: R-Spondin 3 Antibody [NBP1-82234] - Immunohistochemical staining of human tonsil shows moderate to strong membranous positivity in lymphoid cells.

Anti-RSPO3 antibody produced in goat - SAB2501591 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-RSPO3 <B>Cat. No. SAB2501591</B>: (0.3 μg/mL) staining of Human Skeletal Muscle lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-RSPO3 antibody produced in rabbit - HPA029957 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-RSPO3: <B>Cat. No. HPA029957</B>: Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in lymphoid cells outside reaction centra.

RSPO3 Antibody - C-terminal region (ARP60666_P050) - ARP60666_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RSPO3-Antibody-internal-region - AF3389a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF3389a (0.3 µg/ml) staining of Human Skeletal Muscle lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Human/Mouse R-Spondin 3 Antibody - MAB41201 from R&D Systems

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Rat
Clone 400403

Human/Mouse R-Spondin 3 MAb (Clone 400403), Rat IgG2B - MAB41201-SP from R&D Systems

Host Rat
Clonality Monoclonal
Clone 400403

Human R-Spondin 3 Antibody - AF3500 from R&D Systems

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Search more