| Gene Symbol | RSPO3 |
|---|---|
| Entrez Gene | 84870 |
| Alt Symbol | CRISTIN1, PWTSR, THSD2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | R-spondin 3 |
| Other Description | R-spondin 3 homolog|R-spondin-3|protein with TSP type-1 repeat|roof plate-specific spondin-3|thrombospondin type-1 domain-containing protein 2|thrombospondin, type I, domain containing 2 |
| Swissprots | Q96K87 Q5VTV4 B2RC27 Q9BXY4 |
| Accessions | EAW48114 EAW48115 EAW48116 Q9BXY4 AA568446 AF086298 AF251057 AAK34947 AI095468 AK314912 BAG37424 BC022367 AAH22367 DQ891407 ABM82333 DQ894583 ABM85509 NM_032784 NP_116173 |
| Function | Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. {ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22615920}. |
| Subcellular Location | Secreted {ECO:0000250}. |
| Tissue Specificity | Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node. {ECO:0000269|PubMed:12463421}. |