RSPO3

Gene Symbol RSPO3
Entrez Gene 84870
Alt Symbol CRISTIN1, PWTSR, THSD2
Species Human
Gene Type protein-coding
Description R-spondin 3
Other Description R-spondin 3 homolog|R-spondin-3|protein with TSP type-1 repeat|roof plate-specific spondin-3|thrombospondin type-1 domain-containing protein 2|thrombospondin, type I, domain containing 2
Swissprots Q96K87 Q5VTV4 B2RC27 Q9BXY4
Accessions EAW48114 EAW48115 EAW48116 Q9BXY4 AA568446 AF086298 AF251057 AAK34947 AI095468 AK314912 BAG37424 BC022367 AAH22367 DQ891407 ABM82333 DQ894583 ABM85509 NM_032784 NP_116173
Function Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. {ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22615920}.
Subcellular Location Secreted {ECO:0000250}.
Tissue Specificity Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node. {ECO:0000269|PubMed:12463421}.

R-Spondin3 CRISPR/Cas9 KO Plasmid (h) - sc-404472 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

R-Spondin3 HDR Plasmid (h) - sc-404472-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

R-Spondin3 Double Nickase Plasmid (h) - sc-404472-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

R-Spondin3 Double Nickase Plasmid (h2) - sc-404472-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

R-Spondin3 CRISPR Activation Plasmid (h) - sc-404472-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

R-Spondin3 CRISPR Activation Plasmid (h2) - sc-404472-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

R-Spondin3 Lentiviral Activation Particles (h) - sc-404472-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

R-Spondin3 Lentiviral Activation Particles (h2) - sc-404472-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

R-Spondin3 siRNA (h) - sc-95265 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

R-Spondin3 shRNA Plasmid (h) - sc-95265-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

R-Spondin3 shRNA (h) Lentiviral Particles - sc-95265-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU086821 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18720 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18720 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08197 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08197

RSPO3 siRNA (Human) - CRJ3653 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

R-Spondin 3 RNAi - H00084870-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

RSPO3 - MBS8216198 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RSPO3 (NM_032784.3) - SHH400344 from Creative biogene

Category siRNA
Species Reactivities Human

RSPO3 shRNA Plasmid (Human) - CHJ3653 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RSPO3 miRNA 3'UTR clone - MiUTR1H-09056 from Creative biogene

Species Reactivities Human
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