NABP2

Gene Symbol NABP2
Entrez Gene 79035
Alt Symbol OBFC2B, SOSS-B1, SSB1, hSSB1
Species Human
Gene Type protein-coding
Description nucleic acid binding protein 2
Other Description LP3587|SOSS complex subunit B1|nucleic acid-binding protein 2|oligonucleotide/oligosaccharide-binding fold containing 2B|oligonucleotide/oligosaccharide-binding fold-containing protein 2B|sensor of single-strand DNA complex subunit B1|sensor of ssDNA subunit B1|single strand DNA-binding protein 1|single-stranded DNA-binding protein 1
Swissprots A6NDF8 Q9BQ15 Q6XYC8
Accessions EAW96912 EAW96913 EAW96914 EAW96915 Q9BQ15 AI038029 AY203942 AAP34465 BC001079 AAH01079 BC006171 AAH06171 BG697807 HQ447988 ADQ32470 XM_005269146 XP_005269203 XM_005269147 XP_005269204 XM_005269148 XP_005269205 XM_005269149 XP_005269206 NM_024068 NP_076973
Function Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269|PubMed:18449195, ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}.
Subcellular Location Nucleus {ECO:0000269|PubMed:18449195, ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment.

OBFC2B (C-13) - sc-168826 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
OBFC2B (C-13): sc-168826. Western blot analysis of OBFC2B expression in non-transfected: sc-117752 (A) and mouse OBFC2B transfected: sc-122214 (B) 293T whole cell lysates.

Anti-OBFC2B antibody - ab85752 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human colon carcinoma (left) and mouse squamous cell carcinoma (right) tissues labelling OBFC2B with ab85752 at 1/1000 (1µg/ml). Detection: DAB.

Anti-OBFC2B antibody - ab87265 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab87265 at a 1/500 dilution staining OBFC2B in Human colon carcinoma tissue. DAB staining.

Anti-OBFC2B antibody - ab68812 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-OBFC2B antibody (ab68812) at 1/500 dilutionLane 1 : OBFC2B transfected 293T lysateLane 2 : Non-transfected 293T lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-NABP2 Antibody (aa180-211, APC) - LS-C264914 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NABP2 Antibody (aa180-211, Biotin) - LS-C264916 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NABP2 Antibody (aa180-211, AP) - LS-C264913 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NABP2 Antibody (aa180-211, FITC) - LS-C264917 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NABP2 Antibody (aa180-211, PE) - LS-C264921 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NABP2 Antibody (aa180-211, Azide-free, HRP) - LS-C264918 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NABP2 Antibody (aa180-211) - LS-C329923 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NABP2 Antibody (aa183-211) - LS-C163098 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
OBFC2B Antibody western blot of mouse kidney tissue lysates (35 ug/lane). The OBFC2B antibody detected the OBFC2B protein (arrow).

Anti-NABP2 Antibody (clone 1E11) - LS-C173584 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1E11
IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-OBFC2B mouse monoclonal antibody.

Anti-NABP2 Antibody (aa161-211) - LS-C288712 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse SSB1 by Immunohistochemistry. Sample: FFPE sections of human colon carcinoma (left) and mouse squamous cell carcinoma (right). Antibody: Affinity purified rabbit anti-SSB1 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

Anti-NABP2 Antibody (aa161-211) - LS-C286634 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Mouse SSB1 by Immunohistochemistry. Sample: FFPE section of mouse squamous cell carcinoma. Antibody: Affinity purified rabbit anti-SSB1 used at a dilution of 1:100.

OBFC2B Antibody (1E11) - NBP2-01578 from Novus Biologicals

Prices $529.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1E11
Western Blot: OBFC2B Antibody (1E11) [NBP2-01578] Analysis of extracts (35ug) from 9 different cell lines by using anti-OBFC2B monoclonal antibody.

OBFC2B Antibody - NBP1-06561 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: OBFC2B Antibody [NBP1-06561] - Whole cell lysate from HeLa (5, 15 and 50 ug for WB) and 293T (T; 50 ug for WB; 1 mg for IP, 20% of IP loaded) cells. NBP1-06561 used for WB at 0.4 ug/ml (A) and 1 ug/ml (B) and used for IP at 3 ug/mg lysate.

OBFC2B Antibody - NBP1-82718 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: OBFC2B Antibody [NBP1-82718] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

OBFC2B Antibody - H00079035-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-OBFC2B antibody produced in rabbit - HPA044615 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-OBFC2B: <B>Cat. No. HPA044615</B>: Immunohistochemical staining of human pancreas shows strong nuclear positivity in exocrine glandular cells.

Anti-OBFC2B (116-130) antibody produced in rabbit - SAB1102439 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human OBFC2B was separated on SDS-PAGE, blotted with Anti-OBFC2B (116-130) (<B>Cat. No. SAB1102439</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000 <BR/>2. Antibody dilution 1:1,000 + OBFC2B immunizing peptide (human, 116-130)

Anti-OBFC2B (176-190) antibody produced in rabbit - SAB1102440 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells was separated on SDS-PAGE, blotted with Anti-OBFC2B (176-190) (<B>Cat. No. SAB1102440</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:500

Anti-OBFC2B antibody produced in mouse - SAB1407934 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-OBFC2B: <B>Cat. No. SAB1407934</B>: Antibody concentration: 10 μg/mL using HeLa cell.

SOSB1 Antibody - C-terminal region (ARP75753_P050) - ARP75753_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

OBFC2B-Antibody-C-term - AP11591b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
OBFC2B Antibody (C-term) (Cat. #AP11591b) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the OBFC2B antibody detected the OBFC2B protein (arrow).
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