| Gene Symbol |
NABP2
|
| Entrez Gene |
79035
|
| Alt Symbol |
OBFC2B, SOSS-B1, SSB1, hSSB1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nucleic acid binding protein 2
|
| Other Description |
LP3587|SOSS complex subunit B1|nucleic acid-binding protein 2|oligonucleotide/oligosaccharide-binding fold containing 2B|oligonucleotide/oligosaccharide-binding fold-containing protein 2B|sensor of single-strand DNA complex subunit B1|sensor of ssDNA subunit B1|single strand DNA-binding protein 1|single-stranded DNA-binding protein 1
|
| Swissprots |
A6NDF8 Q9BQ15 Q6XYC8
|
| Accessions |
EAW96912 EAW96913 EAW96914 EAW96915 Q9BQ15 AI038029 AY203942 AAP34465 BC001079 AAH01079 BC006171 AAH06171 BG697807 HQ447988 ADQ32470 XM_005269146 XP_005269203 XM_005269147 XP_005269204 XM_005269148 XP_005269205 XM_005269149 XP_005269206 NM_024068 NP_076973
|
| Function |
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269|PubMed:18449195, ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:18449195, ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment.
|