| Gene Symbol | NABP2 |
|---|---|
| Entrez Gene | 79035 |
| Alt Symbol | OBFC2B, SOSS-B1, SSB1, hSSB1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nucleic acid binding protein 2 |
| Other Description | LP3587|SOSS complex subunit B1|nucleic acid-binding protein 2|oligonucleotide/oligosaccharide-binding fold containing 2B|oligonucleotide/oligosaccharide-binding fold-containing protein 2B|sensor of single-strand DNA complex subunit B1|sensor of ssDNA subunit B1|single strand DNA-binding protein 1|single-stranded DNA-binding protein 1 |
| Swissprots | A6NDF8 Q9BQ15 Q6XYC8 |
| Accessions | EAW96912 EAW96913 EAW96914 EAW96915 Q9BQ15 AI038029 AY203942 AAP34465 BC001079 AAH01079 BC006171 AAH06171 BG697807 HQ447988 ADQ32470 XM_005269146 XP_005269203 XM_005269147 XP_005269204 XM_005269148 XP_005269205 XM_005269149 XP_005269206 NM_024068 NP_076973 |
| Function | Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269|PubMed:18449195, ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:18449195, ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment. |
OBFC2B CRISPR/Cas9 KO Plasmid (h) - sc-413117 from Santa Cruz Biotechnology
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OBFC2B HDR Plasmid (h) - sc-413117-HDR from Santa Cruz Biotechnology
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OBFC2B Double Nickase Plasmid (h) - sc-413117-NIC from Santa Cruz Biotechnology
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OBFC2B Double Nickase Plasmid (h2) - sc-413117-NIC-2 from Santa Cruz Biotechnology
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OBFC2B CRISPR Activation Plasmid (h) - sc-413117-ACT from Santa Cruz Biotechnology
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OBFC2B CRISPR Activation Plasmid (h2) - sc-413117-ACT-2 from Santa Cruz Biotechnology
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OBFC2B Lentiviral Activation Particles (h) - sc-413117-LAC from Santa Cruz Biotechnology
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OBFC2B Lentiviral Activation Particles (h2) - sc-413117-LAC-2 from Santa Cruz Biotechnology
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OBFC2B siRNA (h) - sc-95887 from Santa Cruz Biotechnology
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OBFC2B shRNA Plasmid (h) - sc-95887-SH from Santa Cruz Biotechnology
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OBFC2B shRNA (h) Lentiviral Particles - sc-95887-V from Santa Cruz Biotechnology
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OBFC2B RNAi - H00079035-R01 from Novus Biologicals
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MISSION® esiRNA - EHU017251 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15673 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15673 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04268 from Sigma-Aldrich
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NABP2 siRNA (Human) - CRJ2270 from Cohesion Biosciences
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shRNA set against Human OBFC2B (NM_024068.3) - SHH357096 from Creative biogene
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Human NABP2 siRNA - orb272771 from Biorbyt
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NABP2 shRNA Plasmid (Human) - CHJ2270 from Cohesion Biosciences
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NABP2 miRNA 3'UTR clone - MiUTR3H-12296 from Creative biogene
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