Gene Symbol | ORC6 |
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Entrez Gene | 23594 |
Alt Symbol | ORC6L |
Species | Human |
Gene Type | protein-coding |
Description | origin recognition complex, subunit 6 |
Other Description | origin recognition complex subunit 6 |
Swissprots | Q9Y5N6 B3KN89 |
Accessions | EAW82685 EAW82686 Q9Y5N6 AF139658 AAD32666 AK021946 BAG51061 AK024019 BAG51251 AK024077 BAB14817 AK310633 AM392646 CAL37524 AM392910 CAL37788 AM393680 CAL38556 BC039032 AAH39032 BC050725 BC063565 AAH63565 BG822640 XM_011522978 XP_011521280 NM_014321 NP_055136 NR_037620 |
Function | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. {ECO:0000269|PubMed:22427655}. |
Subcellular Location | Nucleus. |
Top Pathways | Cell cycle |
ORC6 CRISPR/Cas9 KO Plasmid (h) - sc-405854 from Santa Cruz Biotechnology
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ORC6 HDR Plasmid (h) - sc-405854-HDR from Santa Cruz Biotechnology
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ORC6 Double Nickase Plasmid (h) - sc-405854-NIC from Santa Cruz Biotechnology
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ORC6 Double Nickase Plasmid (h2) - sc-405854-NIC-2 from Santa Cruz Biotechnology
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ORC6 CRISPR Activation Plasmid (h) - sc-405854-ACT from Santa Cruz Biotechnology
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ORC6 CRISPR Activation Plasmid (h2) - sc-405854-ACT-2 from Santa Cruz Biotechnology
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ORC6 Lentiviral Activation Particles (h) - sc-405854-LAC from Santa Cruz Biotechnology
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ORC6 Lentiviral Activation Particles (h2) - sc-405854-LAC-2 from Santa Cruz Biotechnology
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ORC6 siRNA (h) - sc-38161 from Santa Cruz Biotechnology
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ORC6 shRNA Plasmid (h) - sc-38161-SH from Santa Cruz Biotechnology
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ORC6 shRNA (h) Lentiviral Particles - sc-38161-V from Santa Cruz Biotechnology
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ORC6L RNAi - H00023594-R01 from Novus Biologicals
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MISSION® esiRNA - EHU015151 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16148 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16148 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12350 from Sigma-Aldrich
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ORC6 siRNA (Human) - CRH8384 from Cohesion Biosciences
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ORC6 CRISPR/Cas9 KO Plasmid (h2) - sc-405854-KO-2 from Santa Cruz Biotechnology
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ORC6 HDR Plasmid (h2) - sc-405854-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human ORC6 (NM_014321.3) - SHH368476 from Creative biogene
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ORC6 shRNA Plasmid (Human) - CHH8384 from Cohesion Biosciences
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ORC6 miRNA 3'UTR clone - MiUTR3H-09053 from Creative biogene
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