| Gene Symbol |
SLCO1B3
|
| Entrez Gene |
28234
|
| Alt Symbol |
HBLRR, LST-2, LST-3TM13, LST3, OATP-8, OATP1B3, OATP8, SLC21A8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier organic anion transporter family, member 1B3
|
| Other Description |
liver-specific organic anion transporter 2|liver-specific organic anion transporter 3TM13|organic anion transporter 8|organic anion transporter LST-3c|organic anion-transporting polypeptide 8|solute carrier family 21 (organic anion transporter), member 8|solute carrier organic anion transporter family member 1B3
|
| Swissprots |
E7EMT8 Q5JAR4 Q9NPD5
|
| Accessions |
CAB97008 EAW96413 EAW96414 EAW96415 Q9NPD5 AB669023 AF187815 AAG43445 AJ251506 CAB96997 AK055874 BAG51590 AY342017 AAQ19672 BC022843 AAH22843 BC058006 BC070264 AAH70264 BC105597 AAI05598 BC141525 AAI41526 BG567966 BM968322 NM_019844 NP_062818
|
| Function |
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver. {ECO:0000269|PubMed:22232210}.
|
| Subcellular Location |
Basolateral cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder.
|
| Top Pathways |
Bile secretion
|
![Western Blot: OATP8 Overexpression Lysate (Adult Normal) [NBL1-16204] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for OATP8.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/26137_OATP8%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16204-img0002.jpg)