SLCO1B3

Gene Symbol	SLCO1B3
Entrez Gene	28234
Alt Symbol	HBLRR, LST-2, LST-3TM13, LST3, OATP-8, OATP1B3, OATP8, SLC21A8
Species	Human
Gene Type	protein-coding
Description	solute carrier organic anion transporter family, member 1B3
Other Description	liver-specific organic anion transporter 2|liver-specific organic anion transporter 3TM13|organic anion transporter 8|organic anion transporter LST-3c|organic anion-transporting polypeptide 8|solute carrier family 21 (organic anion transporter), member 8|solute carrier organic anion transporter family member 1B3
Swissprots	E7EMT8 Q5JAR4 Q9NPD5
Accessions	CAB97008 EAW96413 EAW96414 EAW96415 Q9NPD5 AB669023 AF187815 AAG43445 AJ251506 CAB96997 AK055874 BAG51590 AY342017 AAQ19672 BC022843 AAH22843 BC058006 BC070264 AAH70264 BC105597 AAI05598 BC141525 AAI41526 BG567966 BM968322 NM_019844 NP_062818
Function	Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver. {ECO:0000269|PubMed:22232210}.
Subcellular Location	Basolateral cell membrane; Multi-pass membrane protein.
Tissue Specificity	Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder.
Top Pathways	Bile secretion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SLCO1B3 / OATP8 Blocking Peptide - LS-E6278 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SLCO1B3 / OATP8 Antibody Blocking Peptide - LS-E27199 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SLCO1B3-Antibody-C-term-Blocking-Peptide - BP18964b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

OATP8 blocking peptide - GTX88295-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog

SLCO1B3 Peptide - AC21-2019-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SLCO1B3 Peptide - 42-218P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

SLCO1B3 fusion protein - Ag19033 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

SLCO1B3 fusion protein - ag18940 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SLCO1B3, Peptide - MBS426679 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Dog

OATP1B3/SLCO1B3/OATP8 Recombinant Protein Antigen - NBP1-80980PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SLCO1B3 Peptide, Human - M34GP14672H from Creative Peptides Category Peptide Source Synthetic. Species Human

OATP1B3/SLCO1B3/OATP8 Recombinant Protein Antigen - NBP2-54739PEP from Novus Biologicals Category Protein Prices $229.00 Sizes 100 µl Source E.coli Species Human

Solute carrier organic anion transporter family member 1B3 (SLCO1B3), Recombinant Protein - MBS7100928 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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