SLCO1B3

Gene Symbol SLCO1B3
Entrez Gene 28234
Alt Symbol HBLRR, LST-2, LST-3TM13, LST3, OATP-8, OATP1B3, OATP8, SLC21A8
Species Human
Gene Type protein-coding
Description solute carrier organic anion transporter family, member 1B3
Other Description liver-specific organic anion transporter 2|liver-specific organic anion transporter 3TM13|organic anion transporter 8|organic anion transporter LST-3c|organic anion-transporting polypeptide 8|solute carrier family 21 (organic anion transporter), member 8|solute carrier organic anion transporter family member 1B3
Swissprots E7EMT8 Q5JAR4 Q9NPD5
Accessions CAB97008 EAW96413 EAW96414 EAW96415 Q9NPD5 AB669023 AF187815 AAG43445 AJ251506 CAB96997 AK055874 BAG51590 AY342017 AAQ19672 BC022843 AAH22843 BC058006 BC070264 AAH70264 BC105597 AAI05598 BC141525 AAI41526 BG567966 BM968322 NM_019844 NP_062818
Function Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver. {ECO:0000269|PubMed:22232210}.
Subcellular Location Basolateral cell membrane; Multi-pass membrane protein.
Tissue Specificity Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder.
Top Pathways Bile secretion

OATP8 CRISPR/Cas9 KO Plasmid (h) - sc-402371 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OATP8 HDR Plasmid (h) - sc-402371-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OATP8 Double Nickase Plasmid (h) - sc-402371-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OATP8 Double Nickase Plasmid (h2) - sc-402371-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OATP8 CRISPR Activation Plasmid (h) - sc-402371-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OATP8 CRISPR Activation Plasmid (h2) - sc-402371-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OATP8 Lentiviral Activation Particles (h) - sc-402371-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OATP8 Lentiviral Activation Particles (h2) - sc-402371-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OATP8 siRNA (h) - sc-61253 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OATP8 shRNA Plasmid (h) - sc-61253-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OATP8 shRNA (h) Lentiviral Particles - sc-61253-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU107341 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® 3′UTR Lenti GoClone™ - HUTR05051 from Sigma-Aldrich

Category miRNA

SLCO1B3 siRNA (Human) - CRH9115 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

OATP1B3/SLCO1B3/OATP8 RNAi - H00028234-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SLCO1B3 - MBS8241043 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SLCO1B3 (NM_019844.3) - SHH412452 from Creative biogene

Category siRNA
Species Reactivities Human

SLCO1B3 shRNA Plasmid (Human) - CHH9115 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SLCO1B3 miRNA 3'UTR clone - MiUTR3H-07734 from Creative biogene

Species Reactivities Human
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