SKAP1

Gene Symbol	SKAP1
Entrez Gene	8631
Alt Symbol	HEL-S-81p, SCAP1, SKAP55
Species	Human
Gene Type	protein-coding
Description	src kinase associated phosphoprotein 1
Other Description	SKAP-55|epididymis secretory sperm binding protein Li 81p|pp55|src family associated phosphoprotein 1|src family-associated phosphoprotein 1|src kinase-associated phosphoprotein 1|src kinase-associated phosphoprotein of 55 kDa
Swissprots	Q86WV1 D3DTV1 O15268
Accessions	EAW94747 EAW94748 EAW94749 EAW94750 EAW94751 Q86WV1 AK290818 BAF83507 BC039040 BC047870 AAH47870 DR007155 EU668346 ACF94499 Y11215 CAA72101 XM_005257755 XP_005257812 XM_011525408 XP_011523710 XM_011525409 XP_011523711 XM_011525410 XP_011523712 XM_011525411 XP_011523713 XM_011525412 XP_011523714 XM_011525413 XP_011523715 XM_011525414 XP_011523716 XM_011525415 XP_011523717 NM_001075099 NP_001068567 NM_003726 NP_003717
Function	Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. {ECO:0000269|PubMed:10856234, ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:12652296, ECO:0000269|PubMed:15939789, ECO:0000269|PubMed:16980616}.
Subcellular Location	Cytoplasm. Nucleus. Cell membrane. Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane.
Tissue Specificity	Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level). {ECO:0000269|PubMed:9195899}.
Top Pathways	Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SKAP1-Over-expression-Lysate - LY10413a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

SKAP1 overexpression lysate - LY401226 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SKAP1 293 Cell Lysate - 401130 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

SKAP1 293 Cell Lysate - 409502 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

SKAP55 Overexpression Lysate (Native) - NBL1-15987 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SKAP55 Overexpression Lysate (Native) - NBL1-15986 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SKAP55 (h): 293T Lysate - sc-116192 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

SKAP1 Over-expression Lysate Product - GWB-DB06E8 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

SKAP1 Over-expression Lysate Product - GWB-2EC87D from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human SKAP1 Knockdown Stable Cell Line - CSC-DC014285 from Creative biogene Category Cell Line Species Human

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