SKAP1

Gene Symbol SKAP1
Entrez Gene 8631
Alt Symbol HEL-S-81p, SCAP1, SKAP55
Species Human
Gene Type protein-coding
Description src kinase associated phosphoprotein 1
Other Description SKAP-55|epididymis secretory sperm binding protein Li 81p|pp55|src family associated phosphoprotein 1|src family-associated phosphoprotein 1|src kinase-associated phosphoprotein 1|src kinase-associated phosphoprotein of 55 kDa
Swissprots Q86WV1 D3DTV1 O15268
Accessions EAW94747 EAW94748 EAW94749 EAW94750 EAW94751 Q86WV1 AK290818 BAF83507 BC039040 BC047870 AAH47870 DR007155 EU668346 ACF94499 Y11215 CAA72101 XM_005257755 XP_005257812 XM_011525408 XP_011523710 XM_011525409 XP_011523711 XM_011525410 XP_011523712 XM_011525411 XP_011523713 XM_011525412 XP_011523714 XM_011525413 XP_011523715 XM_011525414 XP_011523716 XM_011525415 XP_011523717 NM_001075099 NP_001068567 NM_003726 NP_003717
Function Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. {ECO:0000269|PubMed:10856234, ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:12652296, ECO:0000269|PubMed:15939789, ECO:0000269|PubMed:16980616}.
Subcellular Location Cytoplasm. Nucleus. Cell membrane. Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane.
Tissue Specificity Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level). {ECO:0000269|PubMed:9195899}.
Top Pathways Rap1 signaling pathway

SKAP55 (E-8) - sc-390458 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SKAP55 (E-8): sc-390458. Western blot analysis of SKAP55 expression in non-transfected: sc-117752 (A) and human SKAP55 transfected: sc-116192 (B) 293T whole cell lysates.

SKAP55 (C-17) - sc-9176 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SKAP55 (C-17): sc-9176. Western blot analysis of SKAP55 expression in non-transfected: sc-117752 (A) and human SKAP55 transfected: sc-116192 (B) 293T whole cell lysates.

SKAP55 (N-19) - sc-9175 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SKAP55 (N-19): sc-9175. Western blot analysis of SKAP55 expression in Jurkat (A), SUP-T1 (B), TK-1 (C) whole cell lysates and mouse thymus tissue extract (D).

SKAP55 (35) - sc-136068 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
SKAP55 (35): sc-136068. Western blot analysis of SKAP55 expression in rat thymus tissue extract.

SKAP55 (H-78) - sc-366104 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SKAP55 (H-78): sc-366104. Western blot analysis of SKAP55 expression in Jurkat (A), SUP-T1 (B), NTERA-2 cl.D1 (C), MDA-MB-435S (D), HeLa (E) and CCRF-CEM (F) whole cell lysates.

Anti-SKAP55 antibody - ab19377 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SKAP55 antibody (ab19377) at 1/500 dilutionLane 1 : Human T cell lysateLane 2 : Human platelet lysateLysates/proteins at 20 µg per lane.SecondaryGoat polyclonal to Rabbit IgG conjugated to Odyssey IR-Dye 800 at 1/50000 dilutionPerformed under reducing conditions.

Anti-SKAP55 antibody - ab58316 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
SKAP55 antibody (ab58316) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human tonsil.

Anti-SKAP55 antibody - ab155413 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of paraformaldehyde fixed HeLa cells, labeling SKAP55 with ab155413 at 1/200. Lower image shows costaining with Hoechst 33342.

Anti-SKAP55 antibody - ab80692 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SKAP55 antibody (ab80692) at 1 µg/ml + fetal brain lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-SKAP55 antibody - ab56336 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-SKAP55 antibody [EPR11359] - ab171947 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11359
All lanes : Anti-SKAP55 antibody [EPR11359] (ab171947) at 1/10000 dilutionLane 1 : Molt4 cell line lysateLane 2 : HuT 78 cell line lysateLane 3 : Human thymus tissue lysateLysates/proteins at 10 µg per lane.developed using the ECL technique

Anti-SKAP55 antibody [EPR11360] - ab170882 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11360
All lanes : Anti-SKAP55 antibody [EPR11360] (ab170882) at 1/1000 dilutionLane 1 : Human thymus lysateLane 2 : Jurkat lysateLane 3 : HuT-78 lysateLane 4 : MOLT4 lysateLysates/proteins at 10 µg per lane.SecondaryHRP labeled goat anti-rabbit IgG at 1/2000 dilution

Anti-SKAP1 / SCAP1 Antibody (aa1-358) - LS-C39244 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SKAP1 / SCAP1 Antibody (aa266-295, APC) - LS-C269483 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SKAP1 / SCAP1 Antibody (aa266-295, AP) - LS-C269482 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SKAP1 / SCAP1 Antibody (aa266-295, FITC) - LS-C269484 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SKAP1 / SCAP1 Antibody (aa266-295, Biotin) - LS-C269485 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SKAP1 / SCAP1 Antibody (aa266-295, Azide-free, HRP) - LS-C269486 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SKAP1 / SCAP1 Antibody (aa266-295, PE) - LS-C269487 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SKAP1 / SCAP1 Antibody (FITC) - LS-C317524 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SKAP1 / SCAP1 Antibody (HRP) - LS-C317527 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SKAP1 / SCAP1 Antibody - LS-C285805 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SKAP1 / SCAP1 Antibody (Biotin) - LS-C317526 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SKAP1 / SCAP1 Antibody (aa1-359, Azide-free) - LS-C328745 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-SKAP1 / SCAP1 Antibody (aa265-295) - LS-C325132 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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