SKAP1

Gene Symbol	SKAP1
Entrez Gene	8631
Alt Symbol	HEL-S-81p, SCAP1, SKAP55
Species	Human
Gene Type	protein-coding
Description	src kinase associated phosphoprotein 1
Other Description	SKAP-55|epididymis secretory sperm binding protein Li 81p|pp55|src family associated phosphoprotein 1|src family-associated phosphoprotein 1|src kinase-associated phosphoprotein 1|src kinase-associated phosphoprotein of 55 kDa
Swissprots	Q86WV1 D3DTV1 O15268
Accessions	EAW94747 EAW94748 EAW94749 EAW94750 EAW94751 Q86WV1 AK290818 BAF83507 BC039040 BC047870 AAH47870 DR007155 EU668346 ACF94499 Y11215 CAA72101 XM_005257755 XP_005257812 XM_011525408 XP_011523710 XM_011525409 XP_011523711 XM_011525410 XP_011523712 XM_011525411 XP_011523713 XM_011525412 XP_011523714 XM_011525413 XP_011523715 XM_011525414 XP_011523716 XM_011525415 XP_011523717 NM_001075099 NP_001068567 NM_003726 NP_003717
Function	Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. {ECO:0000269|PubMed:10856234, ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:12652296, ECO:0000269|PubMed:15939789, ECO:0000269|PubMed:16980616}.
Subcellular Location	Cytoplasm. Nucleus. Cell membrane. Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane.
Tissue Specificity	Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level). {ECO:0000269|PubMed:9195899}.
Top Pathways	Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-SKAP1-cDNA-Clone - DC07721 from Abgent, a WuXi AppTec company Prices $484.65 Sizes 10 µg Species Human Accession BC047870

SKAP1 - MBS1274917 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC047870

Human SKAP1 cDNA clone(NM_001075099.1) - CDFH017616 from Creative Biomart Species Human Accession NM_001075099.1

Human SKAP1 ORF Clone(NM_001075099.1) - CDCR344977 from Creative Biomart Species Human Accession NM_001075099.1

Human SKAP1 ORF Clone(NM_001075099.1) - CDCR344978 from Creative Biomart Species Human Accession NM_001075099.1

human SKAP1 ORF clone - CDCH080504 from Creative Biomart Species Human Accession NM_001075099

human SKAP1 ORF clone - CDCH080505 from Creative Biomart Species Human Accession NM_001075099

human SKAP1 ORF clone - CDCH080506 from Creative Biomart Species Human Accession NM_001075099

human SKAP1 ORF clone - CDCH080507 from Creative Biomart Species Human Accession NM_001075099

human SKAP1 ORF clone - CDCH080508 from Creative Biomart Species Human Accession NM_001075099

human SKAP1 ORF clone - CDCH080509 from Creative Biomart Species Human Accession NM_001075099

Human SKAP1 ORF Clone(NM_001075099.1) - CDCL175539 from Creative Biomart Species Human Accession NM_001075099.1

Human SKAP1 Gene ORF cDNA clone in cloning vector - HG13751-G from Sino Biological Species Human

Human SKAP1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13751-NM from Sino Biological Species Human

Human SKAP1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG13751-ANG from Sino Biological Species Human

Human SKAP1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13751-CF from Sino Biological Species Human

Human SKAP1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13751-CM from Sino Biological Species Human

Human SKAP1 Gene ORF cDNA clone expression plasmid, N-His tag - HG13751-NH from Sino Biological Species Human

Human SKAP1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG13751-CY from Sino Biological Species Human

Human SKAP1 Gene ORF cDNA clone expression plasmid - HG13751-UT from Sino Biological Species Human

Human SKAP1 Gene ORF cDNA clone expression plasmid, C-His tag - HG13751-CH from Sino Biological Species Human

Human SKAP1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13751-ACG from Sino Biological Species Human

Human SKAP1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG13751-NY from Sino Biological Species Human

Human SKAP1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG13751-ACR from Sino Biological Species Human

Human SKAP1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG13751-ANR from Sino Biological Species Human

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