SKAP1

Gene Symbol SKAP1
Entrez Gene 8631
Alt Symbol HEL-S-81p, SCAP1, SKAP55
Species Human
Gene Type protein-coding
Description src kinase associated phosphoprotein 1
Other Description SKAP-55|epididymis secretory sperm binding protein Li 81p|pp55|src family associated phosphoprotein 1|src family-associated phosphoprotein 1|src kinase-associated phosphoprotein 1|src kinase-associated phosphoprotein of 55 kDa
Swissprots Q86WV1 D3DTV1 O15268
Accessions EAW94747 EAW94748 EAW94749 EAW94750 EAW94751 Q86WV1 AK290818 BAF83507 BC039040 BC047870 AAH47870 DR007155 EU668346 ACF94499 Y11215 CAA72101 XM_005257755 XP_005257812 XM_011525408 XP_011523710 XM_011525409 XP_011523711 XM_011525410 XP_011523712 XM_011525411 XP_011523713 XM_011525412 XP_011523714 XM_011525413 XP_011523715 XM_011525414 XP_011523716 XM_011525415 XP_011523717 NM_001075099 NP_001068567 NM_003726 NP_003717
Function Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. {ECO:0000269|PubMed:10856234, ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:12652296, ECO:0000269|PubMed:15939789, ECO:0000269|PubMed:16980616}.
Subcellular Location Cytoplasm. Nucleus. Cell membrane. Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane.
Tissue Specificity Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level). {ECO:0000269|PubMed:9195899}.
Top Pathways Rap1 signaling pathway

SKAP55 CRISPR/Cas9 KO Plasmid (h) - sc-405910 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SKAP55 HDR Plasmid (h) - sc-405910-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SKAP55 Double Nickase Plasmid (h) - sc-405910-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SKAP55 Double Nickase Plasmid (h2) - sc-405910-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SKAP55 CRISPR Activation Plasmid (h) - sc-405910-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SKAP55 CRISPR Activation Plasmid (h2) - sc-405910-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SKAP55 Lentiviral Activation Particles (h) - sc-405910-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SKAP55 Lentiviral Activation Particles (h2) - sc-405910-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SKAP55 siRNA (h) - sc-40599 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SKAP55 shRNA Plasmid (h) - sc-40599-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SKAP55 shRNA (h) Lentiviral Particles - sc-40599-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SKAP55 RNAi - H00008631-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU020621 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19376 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19376 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03530 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03530

SKAP1 siRNA (Human) - CRH5671 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SKAP1 - MBS8237846 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SKAP1 (NM_003726.3) - SHH407936 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SKAP1(NM_001075099.1) - SHR227244 from Creative biogene

Category siRNA
Species Reactivities Human

Human SKAP1 siRNA - orb266173 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SKAP1 shRNA Plasmid (Human) - CHH5671 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SKAP1 miRNA 3'UTR clone - MiUTR1H-09418 from Creative biogene

Species Reactivities Human

SKAP1 miRNA 3'UTR clone - MiUTR1H-09419 from Creative biogene

Species Reactivities Human
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