| Gene Symbol |
LAMTOR4
|
| Entrez Gene |
389541
|
| Alt Symbol |
C7orf59
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
|
| Other Description |
UPF0539 protein C7orf59|late endosomal/lysosomal adaptor and MAPK and MTOR activator 4|ragulator complex protein LAMTOR4
|
| Swissprots |
Q0VGL1
|
| Accessions |
CAD61554 EAW76584 EAW76585 Q0VGL1 BC063401 AAH63401 BC105609 AAI05610 BC130553 AAI30554 BC130559 AAI30560 BE733059 BG715626 HQ258033 ADR82787 XM_011516198 XP_011514500 XM_011516199 XP_011514501 NM_001008395 NP_001008396
|
| Function |
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. {ECO:0000269|PubMed:22980980}.
|
| Subcellular Location |
Lysosome {ECO:0000269|PubMed:22980980}.
|