LAMTOR4

Gene Symbol LAMTOR4
Entrez Gene 389541
Alt Symbol C7orf59
Species Human
Gene Type protein-coding
Description late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
Other Description UPF0539 protein C7orf59|late endosomal/lysosomal adaptor and MAPK and MTOR activator 4|ragulator complex protein LAMTOR4
Swissprots Q0VGL1
Accessions CAD61554 EAW76584 EAW76585 Q0VGL1 BC063401 AAH63401 BC105609 AAI05610 BC130553 AAI30554 BC130559 AAI30560 BE733059 BG715626 HQ258033 ADR82787 XM_011516198 XP_011514500 XM_011516199 XP_011514501 NM_001008395 NP_001008396
Function As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. {ECO:0000269|PubMed:22980980}.
Subcellular Location Lysosome {ECO:0000269|PubMed:22980980}.

LOC389541 CRISPR/Cas9 KO Plasmid (h) - sc-408455 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LOC389541 HDR Plasmid (h) - sc-408455-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LOC389541 Double Nickase Plasmid (h) - sc-408455-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LOC389541 Double Nickase Plasmid (h2) - sc-408455-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LOC389541 CRISPR Activation Plasmid (h) - sc-408455-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LOC389541 CRISPR Activation Plasmid (h2) - sc-408455-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LOC389541 Lentiviral Activation Particles (h) - sc-408455-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LOC389541 Lentiviral Activation Particles (h2) - sc-408455-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LAMTOR4 siRNA (h) - sc-89633 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LAMTOR4 shRNA Plasmid (h) - sc-89633-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LAMTOR4 shRNA (h) Lentiviral Particles - sc-89633-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU057661 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5110 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5110 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

LAMTOR4 siRNA (Human) - CRJ7888 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human C7orf59 (NM_001008395.2) - SHH252509 from Creative biogene

Category siRNA
Species Reactivities Human

LAMTOR4 shRNA Plasmid (Human) - CHJ7888 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LAMTOR4 miRNA 3'UTR clone - MiUTR1H-05805 from Creative biogene

Species Reactivities Human
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