Gene Symbol | LAMTOR4 |
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Entrez Gene | 389541 |
Alt Symbol | C7orf59 |
Species | Human |
Gene Type | protein-coding |
Description | late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 |
Other Description | UPF0539 protein C7orf59|late endosomal/lysosomal adaptor and MAPK and MTOR activator 4|ragulator complex protein LAMTOR4 |
Swissprots | Q0VGL1 |
Accessions | CAD61554 EAW76584 EAW76585 Q0VGL1 BC063401 AAH63401 BC105609 AAI05610 BC130553 AAI30554 BC130559 AAI30560 BE733059 BG715626 HQ258033 ADR82787 XM_011516198 XP_011514500 XM_011516199 XP_011514501 NM_001008395 NP_001008396 |
Function | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. {ECO:0000269|PubMed:22980980}. |
Subcellular Location | Lysosome {ECO:0000269|PubMed:22980980}. |
LOC389541 CRISPR/Cas9 KO Plasmid (h) - sc-408455 from Santa Cruz Biotechnology
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LOC389541 HDR Plasmid (h) - sc-408455-HDR from Santa Cruz Biotechnology
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LOC389541 Double Nickase Plasmid (h) - sc-408455-NIC from Santa Cruz Biotechnology
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LOC389541 Double Nickase Plasmid (h2) - sc-408455-NIC-2 from Santa Cruz Biotechnology
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LOC389541 CRISPR Activation Plasmid (h) - sc-408455-ACT from Santa Cruz Biotechnology
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LOC389541 CRISPR Activation Plasmid (h2) - sc-408455-ACT-2 from Santa Cruz Biotechnology
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LOC389541 Lentiviral Activation Particles (h) - sc-408455-LAC from Santa Cruz Biotechnology
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LOC389541 Lentiviral Activation Particles (h2) - sc-408455-LAC-2 from Santa Cruz Biotechnology
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LAMTOR4 siRNA (h) - sc-89633 from Santa Cruz Biotechnology
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LAMTOR4 shRNA Plasmid (h) - sc-89633-SH from Santa Cruz Biotechnology
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LAMTOR4 shRNA (h) Lentiviral Particles - sc-89633-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU057661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5110 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5110 from Sigma-Aldrich
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LAMTOR4 siRNA (Human) - CRJ7888 from Cohesion Biosciences
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shRNA set against Human C7orf59 (NM_001008395.2) - SHH252509 from Creative biogene
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LAMTOR4 shRNA Plasmid (Human) - CHJ7888 from Cohesion Biosciences
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LAMTOR4 miRNA 3'UTR clone - MiUTR1H-05805 from Creative biogene
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