| Gene Symbol |
UBR1
|
| Entrez Gene |
197131
|
| Alt Symbol |
JBS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin protein ligase E3 component n-recognin 1
|
| Other Description |
E3 ubiquitin-protein ligase UBR1|E3a ligase|N-recognin-1|ubiquitin ligase E3 alpha-I|ubiquitin-protein ligase E3-alpha|ubiquitin-protein ligase E3-alpha-1|ubiquitin-protein ligase E3-alpha-I
|
| Swissprots |
Q8IWV7 Q68DN9 Q96JY4 O75492 Q8IWY6 Q14D45 O60708
|
| Accessions |
CCQ43900 EAW92584 Q8IWV7 AF061556 AAC39845 AF525401 AAO14997 AK027803 BAB55380 AK054969 AK056441 AK127478 AK292516 BAF85205 AK302489 BAG63774 AY061886 AAL32103 BC113505 AAI13506 BC113507 AAI13508 BE873236 BX648400 CR749326 CAH18181 NM_174916 NP_777576
|
| Function |
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. {ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:16311597, ECO:0000269|PubMed:20298436, ECO:0000269|PubMed:20835242}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:16311597}.
|
| Tissue Specificity |
Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level). {ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:16311597, ECO:0000269|PubMed:9653112}.
|