UBR1

Gene Symbol UBR1
Entrez Gene 197131
Alt Symbol JBS
Species Human
Gene Type protein-coding
Description ubiquitin protein ligase E3 component n-recognin 1
Other Description E3 ubiquitin-protein ligase UBR1|E3a ligase|N-recognin-1|ubiquitin ligase E3 alpha-I|ubiquitin-protein ligase E3-alpha|ubiquitin-protein ligase E3-alpha-1|ubiquitin-protein ligase E3-alpha-I
Swissprots Q8IWV7 Q68DN9 Q96JY4 O75492 Q8IWY6 Q14D45 O60708
Accessions CCQ43900 EAW92584 Q8IWV7 AF061556 AAC39845 AF525401 AAO14997 AK027803 BAB55380 AK054969 AK056441 AK127478 AK292516 BAF85205 AK302489 BAG63774 AY061886 AAL32103 BC113505 AAI13506 BC113507 AAI13508 BE873236 BX648400 CR749326 CAH18181 NM_174916 NP_777576
Function E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. {ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:16311597, ECO:0000269|PubMed:20298436, ECO:0000269|PubMed:20835242}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:16311597}.
Tissue Specificity Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level). {ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:16311597, ECO:0000269|PubMed:9653112}.

Ubr1 CRISPR/Cas9 KO Plasmid (h) - sc-403943 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ubr1 HDR Plasmid (h) - sc-403943-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ubr1 Double Nickase Plasmid (h) - sc-403943-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ubr1 Double Nickase Plasmid (h2) - sc-403943-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ubr1 CRISPR Activation Plasmid (h) - sc-403943-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ubr1 CRISPR Activation Plasmid (h2) - sc-403943-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ubr1 Lentiviral Activation Particles (h) - sc-403943-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ubr1 Lentiviral Activation Particles (h2) - sc-403943-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ubr1 siRNA (h) - sc-106918 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Ubr1 shRNA Plasmid (h) - sc-106918-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Ubr1 shRNA (h) Lentiviral Particles - sc-106918-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UBR1 RNAi - H00197131-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU053301 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22414 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22414 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11373 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11373

UBR1 siRNA (Human) - CRJ6194 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UBR1 - MBS8206754 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human UBR1 (NM_174916.2) - SHH439520 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human UBR1(NM_174916.2) - SHL103770 from Creative biogene

Category siRNA
Species Reactivities Human

Human UBR1 siRNA - orb276695 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UBR1 shRNA Plasmid (Human) - CHJ6194 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

UBR1 miRNA 3'UTR clone - MiUTR1H-10968 from Creative biogene

Species Reactivities Human
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