UBR1

Gene Symbol	UBR1
Entrez Gene	197131
Alt Symbol	JBS
Species	Human
Gene Type	protein-coding
Description	ubiquitin protein ligase E3 component n-recognin 1
Other Description	E3 ubiquitin-protein ligase UBR1|E3a ligase|N-recognin-1|ubiquitin ligase E3 alpha-I|ubiquitin-protein ligase E3-alpha|ubiquitin-protein ligase E3-alpha-1|ubiquitin-protein ligase E3-alpha-I
Swissprots	Q8IWV7 Q68DN9 Q96JY4 O75492 Q8IWY6 Q14D45 O60708
Accessions	CCQ43900 EAW92584 Q8IWV7 AF061556 AAC39845 AF525401 AAO14997 AK027803 BAB55380 AK054969 AK056441 AK127478 AK292516 BAF85205 AK302489 BAG63774 AY061886 AAL32103 BC113505 AAI13506 BC113507 AAI13508 BE873236 BX648400 CR749326 CAH18181 NM_174916 NP_777576
Function	E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. {ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:16311597, ECO:0000269|PubMed:20298436, ECO:0000269|PubMed:20835242}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:16311597}.
Tissue Specificity	Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level). {ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:16311597, ECO:0000269|PubMed:9653112}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human UBR1 peptide - ab42419 from Abcam Category Peptide

Human UBR1 protein fragment - ab165841 from Abcam Category Protein Source Wheat germ Species Human

UBR1 Antibody Blocking Peptide - LS-E15993 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human UBR1 Protein - H00197131-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

UBR1 Blocking Peptide - 33R-10155 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UBR1 - H00197131-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

UBR1 - H00197131-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

UBR1 fusion protein - ag13589 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T

Recombinant Human E3 ubiquitin-protein ligase UBR1(UBR1) ,partial - CSB-YP812883HU CSB-EP812883HU CSB-BP812883HU CSB-MP812883HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

UBR1 Blocking Peptide - abx161748 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

UBR1 fusion protein - ag22076 from Proteintech Group Category Protein Species Human

UBR1 Recombinant Protein Antigen - NBP1-86253PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

UBR1-Blocking-Peptide-N-term - BP20192a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UBR1 Peptide, Human - M34GP17003H from Creative Peptides Category Peptide Source Synthetic. Species Human

UBR1 Blocking Peptide - CBP4537 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

E3 ubiquitin-protein ligase UBR1 (UBR1), partial, Recombinant Protein - MBS1323810 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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