UBR1

Gene Symbol UBR1
Entrez Gene 197131
Alt Symbol JBS
Species Human
Gene Type protein-coding
Description ubiquitin protein ligase E3 component n-recognin 1
Other Description E3 ubiquitin-protein ligase UBR1|E3a ligase|N-recognin-1|ubiquitin ligase E3 alpha-I|ubiquitin-protein ligase E3-alpha|ubiquitin-protein ligase E3-alpha-1|ubiquitin-protein ligase E3-alpha-I
Swissprots Q8IWV7 Q68DN9 Q96JY4 O75492 Q8IWY6 Q14D45 O60708
Accessions CCQ43900 EAW92584 Q8IWV7 AF061556 AAC39845 AF525401 AAO14997 AK027803 BAB55380 AK054969 AK056441 AK127478 AK292516 BAF85205 AK302489 BAG63774 AY061886 AAL32103 BC113505 AAI13506 BC113507 AAI13508 BE873236 BX648400 CR749326 CAH18181 NM_174916 NP_777576
Function E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. {ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:16311597, ECO:0000269|PubMed:20298436, ECO:0000269|PubMed:20835242}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:16311597}.
Tissue Specificity Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level). {ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:16311597, ECO:0000269|PubMed:9653112}.

Ubr1 (D-18) - sc-5710 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Ubr1 (D-18): sc-5710. Western blot analysis of Ubr1 expression in L8 whole cell lysate.

Ubr1 (P-18) - sc-5711 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Ubr1 (P-18): sc-5711. Immunofluorescence staining of methanol-fixed L8 cells showing cytoplasmic localization.

Ubr1 (24-Z) - sc-100626 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Ubr1 (24-Z): sc-100626. Western blot analysis of Ubr1 expression in HeLa nuclear extract.

Anti-UBR1 antibody - ab108215 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-UBR1 antibody (ab108215) at 0.1 µg/mlLane 1 : Jurkat whole cell lysate at 50 µgLane 2 : Jurkat whole cell lysate at 15 µgLane 3 : Jurkat whole cell lysate at 5 µgdeveloped using the ECL technique

Anti-UBR1 antibody - ab42420 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-UBR1 antibody (ab42420) at 1 µg/mlLane 1 : Skeletal Muscle (Human) Tissue Lysate - adult normal tissue (ab29330)Lane 2 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 3 : HeLa (Human epithelial carcinoma cell line) Nuclear Lysate Lysates/proteins at 20 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-UBR1 antibody - ab138267 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-UBR1 antibody (ab138267) at 1/500 dilution + HUVEC cell lysate at 30 µg

Anti-UBR1 antibody - ab58117 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-UBR1 antibody - N-terminal - ab156436 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-UBR1 antibody - N-terminal (ab156436) at 1/100 dilution + Mouse liver tissue lysate at 35 µg

Anti-UBR1 Antibody (aa245-274, AP) - LS-C218253 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBR1 Antibody (aa245-274, APC) - LS-C218254 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBR1 Antibody (aa245-274, Biotin) - LS-C218255 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBR1 Antibody (aa245-274, FITC) - LS-C218256 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBR1 Antibody (aa245-274, Azide-free, HRP) - LS-C218257 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBR1 Antibody (aa396-445) - LS-C110787 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
UBR1 antibody LS-C110787 Western blot of HepG2 cell lysate.

Anti-UBR1 Antibody (aa245-274, PE) - LS-C218258 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBR1 Antibody (aa225-275) - LS-C289691 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-UBR1 Antibody (aa1125-1175) - LS-C289692 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-UBR1 Antibody (aa245-274) - LS-C326158 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBR1 Antibody (aa821-870) - LS-C119941 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HepG2/Jurkat cells, using UBR1 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-UBR1 Antibody (aa245-274) - LS-C157012 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
UBR1 Antibody western blot of mouse liver tissue lysates (35 ug/lane). The UBR1 antibody detected the UBR1 protein (arrow).

Anti-UBR1 Antibody (aa2-101, Azide-free) - LS-C329030 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-UBR1 Antibody (aa812-861) - LS-C200803 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HUVEC cells using UBR1 antibody.

UBR1 Antibody - NBP1-54976 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: UBR1 Antibody [NBP1-54976] - Titration: 0.2-1 ug/ml, Positive Control: HepG2 cell lysate.

UBR1 Antibody (2F5) - H00197131-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F5

UBR1 Antibody - NBP1-86253 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: UBR1 Antibody [NBP1-86253] - Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & vesicles.
Search more