| Gene Symbol |
FBXL15
|
| Entrez Gene |
79176
|
| Alt Symbol |
FBXO37, Fbl15, JET, PSD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
F-box and leucine-rich repeat protein 15
|
| Other Description |
F-box only protein 37|F-box/LRR-repeat protein 15|pleckstrin and Sec7 domain protein
|
| Swissprots |
B1AKY0 Q5JWA5 Q0D2Q3 B1AKX8 Q9H469 B1AKY1 Q49AL7 A1L4J8 B1AKX9 C9JWA4
|
| Accessions |
EAW49699 Q9H469 AK122684 BC002912 AAH02912 BC036120 AAH36120 BC130566 AAI30567 BI914195 XM_005270149 XP_005270206 XM_005270150 XP_005270207 XM_005270151 XP_005270208 NM_024326 NP_077302
|
| Function |
Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2. {ECO:0000269|PubMed:21572392}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:21572392}.
|