| Gene Symbol | FBXL15 |
|---|---|
| Entrez Gene | 79176 |
| Alt Symbol | FBXO37, Fbl15, JET, PSD |
| Species | Human |
| Gene Type | protein-coding |
| Description | F-box and leucine-rich repeat protein 15 |
| Other Description | F-box only protein 37|F-box/LRR-repeat protein 15|pleckstrin and Sec7 domain protein |
| Swissprots | B1AKY0 Q5JWA5 Q0D2Q3 B1AKX8 Q9H469 B1AKY1 Q49AL7 A1L4J8 B1AKX9 C9JWA4 |
| Accessions | EAW49699 Q9H469 AK122684 BC002912 AAH02912 BC036120 AAH36120 BC130566 AAI30567 BI914195 XM_005270149 XP_005270206 XM_005270150 XP_005270207 XM_005270151 XP_005270208 NM_024326 NP_077302 |
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2. {ECO:0000269|PubMed:21572392}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:21572392}. |
Human-FBXL15-cDNA-Clone - DC14697 from Abgent, a WuXi AppTec company
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FBXL15 - MBS1267629 from MyBioSource
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Human FBXL15 ORF Clone(NM_024326.3) - CDCL163206 from Creative Biomart
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Human FBXL15 ORF Clone(NM_024326.3) - CDCL163207 from Creative Biomart
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Human FBXL15 ORF clone - CDCL107065 from Creative Biomart
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Human FBXL15 ORF clone - CDCL107066 from Creative Biomart
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Human FBXL15 ORF clone - CDCL107067 from Creative Biomart
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Human FBXL15 ORF clone - CDCL107068 from Creative Biomart
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Human FBXL15 ORF clone - CDCL107069 from Creative Biomart
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Human FBXL15 ORF clone - CDCL107070 from Creative Biomart
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Human FBXL15 ORF clone (NM_024326.3) - CDCL107069 from Creative biogene
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Human FBXL15 ORF Clone (BC130566) - CDCS415705 from Creative biogene
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