Gene Symbol | FBXL15 |
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Entrez Gene | 79176 |
Alt Symbol | FBXO37, Fbl15, JET, PSD |
Species | Human |
Gene Type | protein-coding |
Description | F-box and leucine-rich repeat protein 15 |
Other Description | F-box only protein 37|F-box/LRR-repeat protein 15|pleckstrin and Sec7 domain protein |
Swissprots | B1AKY0 Q5JWA5 Q0D2Q3 B1AKX8 Q9H469 B1AKY1 Q49AL7 A1L4J8 B1AKX9 C9JWA4 |
Accessions | EAW49699 Q9H469 AK122684 BC002912 AAH02912 BC036120 AAH36120 BC130566 AAI30567 BI914195 XM_005270149 XP_005270206 XM_005270150 XP_005270207 XM_005270151 XP_005270208 NM_024326 NP_077302 |
Function | Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2. {ECO:0000269|PubMed:21572392}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:21572392}. |
FBL15 CRISPR/Cas9 KO Plasmid (h) - sc-413151 from Santa Cruz Biotechnology
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FBL15 HDR Plasmid (h) - sc-413151-HDR from Santa Cruz Biotechnology
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FBL15 Double Nickase Plasmid (h) - sc-413151-NIC from Santa Cruz Biotechnology
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FBL15 Double Nickase Plasmid (h2) - sc-413151-NIC-2 from Santa Cruz Biotechnology
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FBL15 CRISPR Activation Plasmid (h) - sc-413151-ACT from Santa Cruz Biotechnology
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FBL15 CRISPR Activation Plasmid (h2) - sc-413151-ACT-2 from Santa Cruz Biotechnology
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FBL15 Lentiviral Activation Particles (h) - sc-413151-LAC from Santa Cruz Biotechnology
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FBL15 Lentiviral Activation Particles (h2) - sc-413151-LAC-2 from Santa Cruz Biotechnology
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FBL15 siRNA (h) - sc-90624 from Santa Cruz Biotechnology
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FBL15 shRNA Plasmid (h) - sc-90624-SH from Santa Cruz Biotechnology
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FBL15 shRNA (h) Lentiviral Particles - sc-90624-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN8517 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8517 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00068 from Sigma-Aldrich
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FBXL15 siRNA (Human) - CRJ2348 from Cohesion Biosciences
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FBXL15 - MBS8239852 from MyBioSource
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shRNA set against Human FBXL15 (NM_024326.3) - SHH292849 from Creative biogene
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Human FBXL15 siRNA - orb272849 from Biorbyt
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FBXL15 shRNA Plasmid (Human) - CHJ2348 from Cohesion Biosciences
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FBXL15 miRNA 3'UTR clone - MiUTR3H-11130 from Creative biogene
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