PON3

Gene Symbol PON3
Entrez Gene 5446
Alt Symbol -
Species Human
Gene Type protein-coding
Description paraoxonase 3
Other Description arylesterase 3|paraoxanase-3|serum paraoxonase/lactonase 3
Swissprots Q8IX97 O75855 Q9BZH9 Q6IRU9 A4D1H8 Q15166 O76060
Accessions AAV50000 CBX51401 EAL24132 EAW76768 EAW76770 Q15166 AA860930 AF320003 AAK07629 AF329433 AAO15365 AK096114 AK304282 BAG65142 AV655538 BC020908 BC070374 AAH70374 CD014095 CD014097 CD014100 CD014102 HQ447597 ADQ32083 L48516 AAC41996 NM_000940 NP_000931
Function Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. {ECO:0000269|PubMed:15772423}.
Subcellular Location Secreted, extracellular space {ECO:0000250}.

PON3 (C-19) - sc-21154 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PON3 (C-19): sc-21154. Western blot analysis of PON3 expression in non-transfected: sc-117752 (A) and human PON3 transfected: sc-370782 (B) 293T whole cell lysates.

PON3 (N-20) - sc-21152 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PON3 (N-20): sc-21152. Western blot analysis of PON3 expression in rat skeletal muscle tissue extract.

Anti-PON3 antibody - ab42322 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab42322 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab42322, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-PON3 antibody - ab157486 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PON3 antibody (ab157486) at 1/1000 dilution + K562 cell lysate

Anti-PON3 antibody - ab172100 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-PON3 antibody (ab172100) at 1 µg/mlLane 1 : Lysate from 293T cells transfected with PON3Lane 2 : Lysate from untransfected 293T cellsLysates/proteins at 15 µl per lane.

Anti-PON3 antibody [5G11] - ab71994 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5G11
All lanes : Anti-PON3 antibody [5G11] (ab71994) at 1/2000 dilutionLane 1 : HepG2 cell lysateLane 2 : Hep3B cell lysate

Anti-PON3 antibody [EPR2902(2)] - ab108964 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2902(2)
All lanes : Anti-PON3 antibody [EPR2902(2)] (ab108964) at 1/1000 dilutionLane 1 : Human fetal liver lysateLane 2 : A549 lysateLane 3 : HepG2 lysateLane 4 : Mouse kidney lysateLane 5 : Mouse liver lysateLysates/proteins at 10 µg per lane.

Anti-PON3 antibody [EPR2903(2)] - ab109258 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2903(2)
All lanes : Anti-PON3 antibody [EPR2903(2)] (ab109258) at 1/1000 dilutionLane 1 : Human fetal liver lysateLane 2 : A549 lysateLysates/proteins at 10 µg per lane.

Anti-PON3 antibody - Aminoterminal end - ab93140 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PON3 antibody - Aminoterminal end (ab93140) at 1/100 dilution + HepG2 cell line lysates at 35 µg

Anti-PON3 Antibody (clone 5G11) IHC-plus™ - LS-B7136 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 5G11
Anti-PON3 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7136 dilution 1:400.

Anti-PON3 Antibody (aa30-319, clone 5C3) - LS-C340256 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5C3
IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-PON3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-PON3 Antibody (aa10-38) - LS-C163865 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma with PON3 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-PON3 Antibody (C-Terminus) IHC-plus™ - LS-B6628 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PON3 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6628 concentration 5 ug/ml.

Anti-PON3 Antibody (aa1-354) - LS-C131217 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PON3 Antibody (aa30-354) - LS-C38071 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western analysis of Lysates from human Serum, human A549 and HepG2 cells, mouse liver and spleen tissue and rat liver tissue

Anti-PON3 Antibody (aa10-38, AP) - LS-C280552 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PON3 Antibody (aa10-38, Biotin) - LS-C280553 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PON3 Antibody (aa10-38, APC) - LS-C280554 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PON3 Antibody (Internal, clone EPR2902(2)) - LS-C138069 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2902(2)
Western blot analysis on (A) fetal liver, (B) A549, (C) HepG2, (D) mouse kidney, and (E) mouse liver lysates using anti-PON3 antibody.

Anti-PON3 Antibody (aa143-192) - LS-C110654 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PON3 antibody LS-C110654 Western blot of COLO205 cell lysate.

Anti-PON3 Antibody (aa10-38, FITC) - LS-C280555 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PON3 Antibody (aa10-38, Azide-free, HRP) - LS-C280556 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PON3 Antibody (aa10-38, PE) - LS-C280557 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PON3 Antibody (aa136-354) - LS-C311881 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PON3 Antibody (aa17-46) - LS-C328148 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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