| Gene Symbol |
PON3
|
| Entrez Gene |
5446
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
paraoxonase 3
|
| Other Description |
arylesterase 3|paraoxanase-3|serum paraoxonase/lactonase 3
|
| Swissprots |
Q8IX97 O75855 Q9BZH9 Q6IRU9 A4D1H8 Q15166 O76060
|
| Accessions |
AAV50000 CBX51401 EAL24132 EAW76768 EAW76770 Q15166 AA860930 AF320003 AAK07629 AF329433 AAO15365 AK096114 AK304282 BAG65142 AV655538 BC020908 BC070374 AAH70374 CD014095 CD014097 CD014100 CD014102 HQ447597 ADQ32083 L48516 AAC41996 NM_000940 NP_000931
|
| Function |
Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. {ECO:0000269|PubMed:15772423}.
|
| Subcellular Location |
Secreted, extracellular space {ECO:0000250}.
|
