Gene Symbol | PON3 |
---|---|
Entrez Gene | 5446 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | paraoxonase 3 |
Other Description | arylesterase 3|paraoxanase-3|serum paraoxonase/lactonase 3 |
Swissprots | Q8IX97 O75855 Q9BZH9 Q6IRU9 A4D1H8 Q15166 O76060 |
Accessions | AAV50000 CBX51401 EAL24132 EAW76768 EAW76770 Q15166 AA860930 AF320003 AAK07629 AF329433 AAO15365 AK096114 AK304282 BAG65142 AV655538 BC020908 BC070374 AAH70374 CD014095 CD014097 CD014100 CD014102 HQ447597 ADQ32083 L48516 AAC41996 NM_000940 NP_000931 |
Function | Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. {ECO:0000269|PubMed:15772423}. |
Subcellular Location | Secreted, extracellular space {ECO:0000250}. |
PON3 CRISPR/Cas9 KO Plasmid (h) - sc-409518 from Santa Cruz Biotechnology
|
||||||||
PON3 HDR Plasmid (h) - sc-409518-HDR from Santa Cruz Biotechnology
|
||||||||
PON3 Double Nickase Plasmid (h) - sc-409518-NIC from Santa Cruz Biotechnology
|
||||||||
PON3 Double Nickase Plasmid (h2) - sc-409518-NIC-2 from Santa Cruz Biotechnology
|
||||||||
PON3 CRISPR Activation Plasmid (h) - sc-409518-ACT from Santa Cruz Biotechnology
|
||||||||
PON3 CRISPR Activation Plasmid (h2) - sc-409518-ACT-2 from Santa Cruz Biotechnology
|
||||||||
PON3 Lentiviral Activation Particles (h) - sc-409518-LAC from Santa Cruz Biotechnology
|
||||||||
PON3 Lentiviral Activation Particles (h2) - sc-409518-LAC-2 from Santa Cruz Biotechnology
|
||||||||
PON3 siRNA (h) - sc-106429 from Santa Cruz Biotechnology
|
||||||||
PON3 shRNA Plasmid (h) - sc-106429-SH from Santa Cruz Biotechnology
|
||||||||
PON3 shRNA (h) Lentiviral Particles - sc-106429-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU131621 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN17153 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17153 from Sigma-Aldrich
|
||||||||
PON3 siRNA (Human) - CRH3649 from Cohesion Biosciences
|
||||||||
shRNA set against Human PON3 (NM_000940.2) - SHH379804 from Creative biogene
|
||||||||
shRNA set against Human PON3(NM_000940.2) - SHR128904 from Creative biogene
|
||||||||
Human PON3 siRNA - orb264151 from Biorbyt
|
||||||||
PON3 shRNA Plasmid (Human) - CHH3649 from Cohesion Biosciences
|
||||||||
PON3 miRNA 3'UTR clone - MiUTR1H-08095 from Creative biogene
|