RIPK1

Gene Symbol	RIPK1
Entrez Gene	8737
Alt Symbol	RIP, RIP1
Species	Human
Gene Type	protein-coding
Description	receptor (TNFRSF)-interacting serine-threonine kinase 1
Other Description	RIP-1|cell death protein RIP|receptor interacting protein|receptor-interacting protein 1|receptor-interacting serine/threonine-protein kinase 1|serine/threonine-protein kinase RIP
Swissprots	Q59H33 B4E3F9 B2RAG1 Q13546 Q13180 A0AV89
Accessions	AAT74626 EAW55115 EAW55116 EAW55117 EAW55118 Q13546 AB208926 BAD92163 AJ420482 AK096523 BAG53315 AK304701 BAG65471 AK314176 BAG36858 BC126254 AAI26255 BC126256 AAI26257 BX348786 HQ258488 ADR83242 U25994 AAC50137 U50062 AAC32232 XM_005249457 XP_005249514 XM_005249458 XP_005249515 XM_006715237 XP_006715300 XM_011514969 XP_011513271 NM_003804 NP_003795
Function	Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 asso
Subcellular Location	Cytoplasm. Cell membrane {ECO:0000250}.
Top Pathways	Apoptosis, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Hepatitis C

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RIPK1 / RIP ELISA Kit (Sandwich ELISA) - LS-F9254 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Rat RIPK1 / RIP ELISA Kit (Sandwich ELISA) - LS-F9518 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.055 ng/ml Range 0.156-10 ng/ml

RalA Binding Protein 1 (RALBP1), Human, ELISA Kit - SEH265Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.058ng/mL Range 0.156-10ng/mL

Receptor Interacting Serine Threonine Kinase 1 (RIPK1), Human, ELISA Kit - SEE640Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.057ng/mL Range 0.156-10ng/mL

ELISA Kit for Receptor Interacting Serine Threonine Kinase 1 (RIPK1) - SEE640Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.057ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Receptor Interacting Serine Threonine Kinase 1 (RIPK1) - SEE640Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.055ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for RalA Binding Protein 1 (RALBP1) - SEH265Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.058ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Receptor Interacting Serine Threonine Kinase 1 (RIPK1) - SEE640Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.057ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human RIPK1 ELISA Kit - abx152974 from Abbexa Category ELISA Kit Sensitivity 0.057 ng/ml Range 0.156 ng/ml - 10 ng/ml

Receptor Interacting Serine Threonine Kinase 1 (RIPK1), Human, ELISA Kit - DL-RIPK1-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human RIPK1 ELISA Kit - abx571730 from Abbexa Category ELISA Kit Sensitivity 0.057 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human RIPK1 ELISA Kit - E033006 from Biobool Category ELISA Kit Sensitivity Typically less than 0.057ng/mL.

RIPK1 ELISA Kit (Human) (OKCD00436) - OKCD00436 from Aviva Systems Biology Category ELISA Kit Prices $545.00 Sizes 96 wells Sensitivity < 0.063 ng/mL Range 0.156-10 ng/mL

RIPK1 ELISA Kit (Human) (OKDD00507) - OKDD00507 from Aviva Systems Biology Category ELISA Kit Prices $580.00 Sizes 96 wells Sensitivity < 0.057 ng/mL Range 0.156-10 ng/mL

Human Receptor-interacting serine/threonine-protein kinase 1 ELISA Kit - EK3745 from Signalway Antibody Category ELISA Kit Prices $739.00 Sizes 1x96t Range 0.15 ng/mL -10.0 ng/mL

anti-RIP1 antibody - ARG56458 from Arigo Biolaboratories Category ELISA Kit

anti-RIP1 antibody - ARG55746 from Arigo Biolaboratories Category ELISA Kit

Human Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) ELISA Kit - AE22081HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.063 ng/mL Range 0.156-10 ng/mL

Receptor Interacting Serine Threonine Kinase 1 (RIPK1), ELISA Kit - MBS454320 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.057ng/mL Range 0.156-10ng/mL

Receptor-interacting serine/threonine-protein kinase 1, ELISA Kit - MBS9427575 from MyBioSource Category ELISA Kit Prices $670.00 Sizes 96 tests Range 31.2-2000 pg/mL

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