RIPK1

Gene Symbol RIPK1
Entrez Gene 8737
Alt Symbol RIP, RIP1
Species Human
Gene Type protein-coding
Description receptor (TNFRSF)-interacting serine-threonine kinase 1
Other Description RIP-1|cell death protein RIP|receptor interacting protein|receptor-interacting protein 1|receptor-interacting serine/threonine-protein kinase 1|serine/threonine-protein kinase RIP
Swissprots Q59H33 B4E3F9 B2RAG1 Q13546 Q13180 A0AV89
Accessions AAT74626 EAW55115 EAW55116 EAW55117 EAW55118 Q13546 AB208926 BAD92163 AJ420482 AK096523 BAG53315 AK304701 BAG65471 AK314176 BAG36858 BC126254 AAI26255 BC126256 AAI26257 BX348786 HQ258488 ADR83242 U25994 AAC50137 U50062 AAC32232 XM_005249457 XP_005249514 XM_005249458 XP_005249515 XM_006715237 XP_006715300 XM_011514969 XP_011513271 NM_003804 NP_003795
Function Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 asso
Subcellular Location Cytoplasm. Cell membrane {ECO:0000250}.
Top Pathways Apoptosis, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Hepatitis C

RIP (D94C12) XP ® Rabbit mAb (PE Conjugate) - 14577 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D94C12
Flow cytometric analysis of MCF7 cells using RIP (D94C12) XP ® Rabbit mAb (PE Conjugate) (green) compared to concentration-matched Rabbit (DA1E) mAb IgG XP ® Isotype Control (PE Conjugate) #5742 (red).

RIP (D94C12) XP ® Rabbit mAb - 3493 from Cell Signaling Technology

Prices $109.00, $277.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D94C12
Western blot analysis of extracts from various cell lines using RIP (D94C12) XP ® Rabbit mAb.

RIP Antibody - 4926 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HL-60, MOLT-4 and Raji cell lines, using RIP Antibody.

RIP (C-12) - sc-133102 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RIP (C-12): sc-133102. Western blot analysis of RIP expression in HeLa (A) and TNFα-treated HeLa (B) whole cell lysates.

RIP (H-207) - sc-7881 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RIP (H-207): sc-7881. Western blot analysis of RIP expression in HeLa whole cell lysate.

RIP (K-20) - sc-1169 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RIP (K-20): sc-1169. Western blot analysis of human RIP carboxy terminal domain-containing fusion protein.

Anti-RIP antibody - ab106393 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-RIP antibody (ab106393) at 1 µg/ml + Rat kidney tissue lysate at 15 µg

Anti-RIP antibody - ab137451 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-RIP antibody (ab137451) at 1/5000 dilution + MOLT4 whole cell lysate at 30 µg

Anti-RIP antibody - ab2035 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RIP antibody - ab2563 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-RIP antibody [2D6] - ab131638 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2D6
Overlay histogram showing HEK293 cells stained with ab131638 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab131638, 1/100 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-RIP antibody [7H10] - ab72139 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7H10
All lanes : Anti-RIP antibody [7H10] (ab72139) at 1/500 dilutionLane 1 : K562 cell lysateLane 2 : HeLa cell lysateLane 3 : SK-N-MC cell lysate

Anti-RIP antibody [EPR4689] - ab125072 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4689
All lanes : Anti-RIP antibody [EPR4689] (ab125072) at 1/1000 dilutionLane 1 : Raji cell lysateLane 2 : Jurkat cell lysateLane 3 : HeLa cell lysateLane 4 : 293T cell lysateLysates/proteins at 10 µg per lane.

Anti-RIP antibody [EPR4689-100] - ab178420 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4689-100
All lanes : Anti-RIP antibody [EPR4689-100] (ab178420) at 1/1000 dilutionLane 1 : Raji cell lysateLane 2 : HeLa cell lysate with StaurosporineLane 3 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-RIPK1 / RIP Antibody (clone 2G3) IHC-plus™ - LS-B11088 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 2G3
Anti-RIPK1 / RIP antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11088 concentration 10 ug/ml.

Anti-RIPK1 / RIP Antibody (N-Terminus) IHC-plus™ - LS-B4613 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-RIPK1 /RIP antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4613 concentration 5 ug/ml.

Anti-RIPK1 / RIP Antibody (clone 2D6) - LS-C175237 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2D6
IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-RIPK1 mouse monoclonal antibody.

Anti-RIPK1 / RIP Antibody - LS-C48287 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RIPK1 / RIP Antibody (aa337-525) - LS-C38924 from LifeSpan Bioscience

Prices $475.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-RIPK1 / RIP Antibody (aa1-430) - LS-C93309 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-RIPK1 / RIP Antibody (aa411-460) - LS-C29834 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Jurkat Cell Lysate

Anti-RIPK1 / RIP Antibody (aa350-400) - LS-C47381 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of humanRIP1inramos cell lysate in the 1) absence and2) presence of immunizing peptide using antibody at2 ug/ml.

Anti-RIPK1 / RIP Antibody (aa306-449, clone EPR4689) - LS-C138428 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4689
Western blot analysis on (A) Raji, (B) Jurkat, (C) HeLa, and (D) 293T cell lysates using anti-RIP antibody.

Anti-RIPK1 / RIP Antibody (aa152-180, AP) - LS-C268282 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RIPK1 / RIP Antibody (aa152-180, APC) - LS-C268283 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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