RIPK1
| Gene Symbol | RIPK1 |
|---|---|
| Entrez Gene | 8737 |
| Alt Symbol | RIP, RIP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | receptor (TNFRSF)-interacting serine-threonine kinase 1 |
| Other Description | RIP-1|cell death protein RIP|receptor interacting protein|receptor-interacting protein 1|receptor-interacting serine/threonine-protein kinase 1|serine/threonine-protein kinase RIP |
| Swissprots | Q59H33 B4E3F9 B2RAG1 Q13546 Q13180 A0AV89 |
| Accessions | AAT74626 EAW55115 EAW55116 EAW55117 EAW55118 Q13546 AB208926 BAD92163 AJ420482 AK096523 BAG53315 AK304701 BAG65471 AK314176 BAG36858 BC126254 AAI26255 BC126256 AAI26257 BX348786 HQ258488 ADR83242 U25994 AAC50137 U50062 AAC32232 XM_005249457 XP_005249514 XM_005249458 XP_005249515 XM_006715237 XP_006715300 XM_011514969 XP_011513271 NM_003804 NP_003795 |
| Function | Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 asso |
| Subcellular Location | Cytoplasm. Cell membrane {ECO:0000250}. |
| Top Pathways | Apoptosis, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Hepatitis C |
RIP CRISPR/Cas9 KO Plasmid (h) - sc-400377 from Santa Cruz Biotechnology
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RIP HDR Plasmid (h) - sc-400377-HDR from Santa Cruz Biotechnology
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RIP Double Nickase Plasmid (h) - sc-400377-NIC from Santa Cruz Biotechnology
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RIP Double Nickase Plasmid (h2) - sc-400377-NIC-2 from Santa Cruz Biotechnology
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RIP CRISPR Activation Plasmid (h) - sc-400377-ACT from Santa Cruz Biotechnology
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RIP CRISPR Activation Plasmid (h2) - sc-400377-ACT-2 from Santa Cruz Biotechnology
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RIP Lentiviral Activation Particles (h) - sc-400377-LAC from Santa Cruz Biotechnology
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RIP Lentiviral Activation Particles (h2) - sc-400377-LAC-2 from Santa Cruz Biotechnology
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RIP siRNA (h) - sc-36426 from Santa Cruz Biotechnology
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RIP shRNA Plasmid (h) - sc-36426-SH from Santa Cruz Biotechnology
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RIP shRNA (h) Lentiviral Particles - sc-36426-V from Santa Cruz Biotechnology
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RIP-GFP shRNA (h) Lentiviral Particles - sc-36426-VG from Santa Cruz Biotechnology
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RIP siRNA (h2) - sc-44326 from Santa Cruz Biotechnology
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RIP shRNA Plasmid (h2) - sc-44326-SH from Santa Cruz Biotechnology
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RIP shRNA (h2) Lentiviral Particles - sc-44326-V from Santa Cruz Biotechnology
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RIPK1/RIP1 RNAi - H00008737-R02 from Novus Biologicals
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MISSION® esiRNA - EHU155791 from Sigma-Aldrich
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MISSION® siRNA - SIHK1963 from Sigma-Aldrich
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MISSION® siRNA - SIHK1964 from Sigma-Aldrich
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MISSION® siRNA - SIHK1962 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1066 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1066 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10496 from Sigma-Aldrich
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RIPK1 siRNA (Human) - CRH5755 from Cohesion Biosciences
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RIPK1 - MBS8205573 from MyBioSource
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