| Gene Symbol |
RIPK1
|
| Entrez Gene |
8737
|
| Alt Symbol |
RIP, RIP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
receptor (TNFRSF)-interacting serine-threonine kinase 1
|
| Other Description |
RIP-1|cell death protein RIP|receptor interacting protein|receptor-interacting protein 1|receptor-interacting serine/threonine-protein kinase 1|serine/threonine-protein kinase RIP
|
| Swissprots |
Q59H33 B4E3F9 B2RAG1 Q13546 Q13180 A0AV89
|
| Accessions |
AAT74626 EAW55115 EAW55116 EAW55117 EAW55118 Q13546 AB208926 BAD92163 AJ420482 AK096523 BAG53315 AK304701 BAG65471 AK314176 BAG36858 BC126254 AAI26255 BC126256 AAI26257 BX348786 HQ258488 ADR83242 U25994 AAC50137 U50062 AAC32232 XM_005249457 XP_005249514 XM_005249458 XP_005249515 XM_006715237 XP_006715300 XM_011514969 XP_011513271 NM_003804 NP_003795
|
| Function |
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 asso
|
| Subcellular Location |
Cytoplasm. Cell membrane {ECO:0000250}.
|
| Top Pathways |
Apoptosis, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Hepatitis C
|
![Western Blot: RIPK1 Overexpression Lysate (Adult Normal) [NBL1-15377] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RIPK1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5606_RIPK1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15377-img0002.jpg)