RIPK1

Gene Symbol	RIPK1
Entrez Gene	8737
Alt Symbol	RIP, RIP1
Species	Human
Gene Type	protein-coding
Description	receptor (TNFRSF)-interacting serine-threonine kinase 1
Other Description	RIP-1|cell death protein RIP|receptor interacting protein|receptor-interacting protein 1|receptor-interacting serine/threonine-protein kinase 1|serine/threonine-protein kinase RIP
Swissprots	Q59H33 B4E3F9 B2RAG1 Q13546 Q13180 A0AV89
Accessions	AAT74626 EAW55115 EAW55116 EAW55117 EAW55118 Q13546 AB208926 BAD92163 AJ420482 AK096523 BAG53315 AK304701 BAG65471 AK314176 BAG36858 BC126254 AAI26255 BC126256 AAI26257 BX348786 HQ258488 ADR83242 U25994 AAC50137 U50062 AAC32232 XM_005249457 XP_005249514 XM_005249458 XP_005249515 XM_006715237 XP_006715300 XM_011514969 XP_011513271 NM_003804 NP_003795
Function	Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 asso
Subcellular Location	Cytoplasm. Cell membrane {ECO:0000250}.
Top Pathways	Apoptosis, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Hepatitis C

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human RIP full length protein - ab190411 from Abcam Category Protein Prices $1,051.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human RIP full length protein - ab135220 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human RIP protein fragment - ab152911 from Abcam Category Protein Source Wheat germ Species Human

KRR1 Antibody Blocking Peptide - LS-E4736 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RIP1 / RALBP1 Antibody Blocking Peptide - LS-E18773 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RIP1 / RALBP1 Antibody Blocking Peptide - LS-E6606 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RIPK1 / RIP Antibody Blocking Peptide - LS-E2789 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RIPK1 / RIP Antibody Blocking Peptide - LS-E10644 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RIPK1 / RIP Antibody Blocking Peptide - LS-E30773 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

RIPK1 / RIP Antibody Blocking Peptide - LS-E30062 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human RIPK1/RIP1 Protein - H00008737-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RIPK1/RIP1 Blocking Peptide - NBP1-77077PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

RIPK1/RIP1 Peptide - P2840 from Novus Biologicals Category Peptide Species Human

RIPK1-Antibody-N-term-Blocking-peptide - BP13893a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RIPK1-Antibody-C-term-Blocking-Peptide - BP7817b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RIP Blocking Peptide - 33R-10699 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

RIPK1 Blocking Peptide - 33R-8158 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RIP - H00008737-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RIP - H00008737-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RIP - H00008737-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RIP - H00008737-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RIP Control Peptide - AP30730CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

RIP1 Peptide - 3291P from ProSci Category Peptide Species Human

RIPK1 Peptide - 5389P from ProSci Category Peptide Species Human

Recombinant Human RIPK1, GST-tagged - RIPK1-7018H from Creative Biomart Category Protein Source Sf9 Cells Species Human

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