| Gene Symbol |
PYHIN1
|
| Entrez Gene |
149628
|
| Alt Symbol |
IFIX
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pyrin and HIN domain family, member 1
|
| Other Description |
interferon-inducible protein X|pyrin and HIN domain-containing protein 1
|
| Swissprots |
Q6K0P8 Q6K0P9 Q8WW65 Q6K0P7 Q5T3W6 Q6K0P6
|
| Accessions |
EAW52805 Q6K0P9 AK024890 AK308350 AW518129 AY185344 AAO67506 AY185345 AAO67507 AY185346 AAO67508 AY185347 AAO67509 BC020822 AAH20822 BC073133 BC090944 AAH90944 BC114470 BC139741 AAI39742 DB126431 DB188734 XM_005244930 XP_005244987 XM_011509242 XP_011507544 XM_011509243 XP_011507545 NM_152501 NP_689714 NM_198928 NP_945146 NM_198929 NP_945147 NM_198930 NP_945148
|
| Function |
Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. {ECO:0000269|PubMed:16479015, ECO:0000269|PubMed:18247378}.
|
| Subcellular Location |
Isoform 5: Nucleus. Nucleus speckle.
|
| Tissue Specificity |
Expressed in spleen, lymph node and peripheral blood leukocytes, and at lower levels in thymus, bone marrow and fetal liver. Down-regulated in breast tumors. {ECO:0000269|PubMed:15122330}.
|