PYHIN1

Gene Symbol	PYHIN1
Entrez Gene	149628
Alt Symbol	IFIX
Species	Human
Gene Type	protein-coding
Description	pyrin and HIN domain family, member 1
Other Description	interferon-inducible protein X|pyrin and HIN domain-containing protein 1
Swissprots	Q6K0P8 Q6K0P9 Q8WW65 Q6K0P7 Q5T3W6 Q6K0P6
Accessions	EAW52805 Q6K0P9 AK024890 AK308350 AW518129 AY185344 AAO67506 AY185345 AAO67507 AY185346 AAO67508 AY185347 AAO67509 BC020822 AAH20822 BC073133 BC090944 AAH90944 BC114470 BC139741 AAI39742 DB126431 DB188734 XM_005244930 XP_005244987 XM_011509242 XP_011507544 XM_011509243 XP_011507545 NM_152501 NP_689714 NM_198928 NP_945146 NM_198929 NP_945147 NM_198930 NP_945148
Function	Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. {ECO:0000269|PubMed:16479015, ECO:0000269|PubMed:18247378}.
Subcellular Location	Isoform 5: Nucleus. Nucleus speckle.
Tissue Specificity	Expressed in spleen, lymph node and peripheral blood leukocytes, and at lower levels in thymus, bone marrow and fetal liver. Down-regulated in breast tumors. {ECO:0000269|PubMed:15122330}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PYHIN1 full length protein - ab165593 from Abcam Category Protein Source Wheat germ Species Human

IFIX / PYHIN1 Antibody Blocking Peptide - LS-E18372 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PYHIN1 Protein - H00149628-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

PYHIN1 Blocking Peptide - 33R-1404 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PYHIN1 Blocking Peptide - 33R-4554 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PYHIN1 - H00149628-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

PYHIN1 fusion protein - Ag19165 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

PYHIN1 fusion protein - Ag19067 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human Pyrin and HIN domain-containing protein 1(PYHIN1) - CSB-YP746957HU CSB-EP746957HU CSB-BP746957HU CSB-MP746957HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PYHIN1 Recombinant Protein Antigen - NBP2-13835PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PYHIN1-Blocking-Peptide-N-term - BP5376a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PYHIN1 Peptide, Human - M34GP12785H from Creative Peptides Category Peptide Source Synthetic. Species Human

Pyrin and HIN domain-containing protein 1 (PYHIN1), Recombinant Protein - MBS1408057 from MyBioSource Category Protein Prices $1,280.00, $1,280.00, $1,495.00, $1,495.00, $2,095.00, $2,095.00, $2,560.00, $2,560.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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