PYHIN1

Gene Symbol PYHIN1
Entrez Gene 149628
Alt Symbol IFIX
Species Human
Gene Type protein-coding
Description pyrin and HIN domain family, member 1
Other Description interferon-inducible protein X|pyrin and HIN domain-containing protein 1
Swissprots Q6K0P8 Q6K0P9 Q8WW65 Q6K0P7 Q5T3W6 Q6K0P6
Accessions EAW52805 Q6K0P9 AK024890 AK308350 AW518129 AY185344 AAO67506 AY185345 AAO67507 AY185346 AAO67508 AY185347 AAO67509 BC020822 AAH20822 BC073133 BC090944 AAH90944 BC114470 BC139741 AAI39742 DB126431 DB188734 XM_005244930 XP_005244987 XM_011509242 XP_011507544 XM_011509243 XP_011507545 NM_152501 NP_689714 NM_198928 NP_945146 NM_198929 NP_945147 NM_198930 NP_945148
Function Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. {ECO:0000269|PubMed:16479015, ECO:0000269|PubMed:18247378}.
Subcellular Location Isoform 5: Nucleus. Nucleus speckle.
Tissue Specificity Expressed in spleen, lymph node and peripheral blood leukocytes, and at lower levels in thymus, bone marrow and fetal liver. Down-regulated in breast tumors. {ECO:0000269|PubMed:15122330}.

IFIX CRISPR/Cas9 KO Plasmid (h) - sc-414664 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IFIX HDR Plasmid (h) - sc-414664-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IFIX Double Nickase Plasmid (h) - sc-414664-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IFIX Double Nickase Plasmid (h2) - sc-414664-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IFIX CRISPR Activation Plasmid (h) - sc-414664-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IFIX CRISPR Activation Plasmid (h2) - sc-414664-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IFIX Lentiviral Activation Particles (h) - sc-414664-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IFIX Lentiviral Activation Particles (h2) - sc-414664-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IFIX siRNA (h) - sc-88428 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IFIX shRNA Plasmid (h) - sc-88428-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IFIX shRNA (h) Lentiviral Particles - sc-88428-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU128891 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17775 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17775 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03052 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03052

PYHIN1 siRNA (Human) - CRJ5626 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PYHIN1 (NM_152501.4) - SHH387488 from Creative biogene

Category siRNA
Species Reactivities Human

Human PYHIN1 siRNA - orb276127 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PYHIN1 shRNA Plasmid (Human) - CHJ5626 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PYHIN1 miRNA 3'UTR clone - MiUTR3H-12540 from Creative biogene

Species Reactivities Human

PYHIN1 miRNA 3'UTR clone - MiUTR3H-12541 from Creative biogene

Species Reactivities Human

PYHIN1 miRNA 3'UTR clone - MiUTR3H-12542 from Creative biogene

Species Reactivities Human

PYHIN1 miRNA 3'UTR clone - MiUTR3H-12543 from Creative biogene

Species Reactivities Human
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