PYHIN1

Gene Symbol	PYHIN1
Entrez Gene	149628
Alt Symbol	IFIX
Species	Human
Gene Type	protein-coding
Description	pyrin and HIN domain family, member 1
Other Description	interferon-inducible protein X|pyrin and HIN domain-containing protein 1
Swissprots	Q6K0P8 Q6K0P9 Q8WW65 Q6K0P7 Q5T3W6 Q6K0P6
Accessions	EAW52805 Q6K0P9 AK024890 AK308350 AW518129 AY185344 AAO67506 AY185345 AAO67507 AY185346 AAO67508 AY185347 AAO67509 BC020822 AAH20822 BC073133 BC090944 AAH90944 BC114470 BC139741 AAI39742 DB126431 DB188734 XM_005244930 XP_005244987 XM_011509242 XP_011507544 XM_011509243 XP_011507545 NM_152501 NP_689714 NM_198928 NP_945146 NM_198929 NP_945147 NM_198930 NP_945148
Function	Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. {ECO:0000269|PubMed:16479015, ECO:0000269|PubMed:18247378}.
Subcellular Location	Isoform 5: Nucleus. Nucleus speckle.
Tissue Specificity	Expressed in spleen, lymph node and peripheral blood leukocytes, and at lower levels in thymus, bone marrow and fetal liver. Down-regulated in breast tumors. {ECO:0000269|PubMed:15122330}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-PYHIN1-cDNA-Clone - DC14875 from Abgent, a WuXi AppTec company Prices $330.75 Sizes 10 µg Species Human Accession BC020822

PYHIN1 - MBS1265929 from MyBioSource Species Human Accession BC139741

PYHIN1 - MBS1278024 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC020822

Human PYHIN1 Gene ORF cDNA clone in cloning vector - HG15657-G from Sino Biological Species Human

Human PYHIN1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG15657-CF from Sino Biological Species Human

Human PYHIN1 Gene ORF cDNA clone expression plasmid, C-His tag - HG15657-CH from Sino Biological Species Human

Human PYHIN1 Gene ORF cDNA clone expression plasmid, N-His tag - HG15657-NH from Sino Biological Species Human

Human PYHIN1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG15657-CM from Sino Biological Species Human

Human PYHIN1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG15657-NM from Sino Biological Species Human

Human PYHIN1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG15657-CY from Sino Biological Species Human

Human PYHIN1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG15657-ANG from Sino Biological Species Human

Human PYHIN1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG15657-ACG from Sino Biological Species Human

Human PYHIN1 Gene ORF cDNA clone expression plasmid - HG15657-UT from Sino Biological Species Human

Human PYHIN1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-FLAG-tagged - HG15657-NF from Sino Biological Species Human Accession BC139741

Human PYHIN1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG15657-NY from Sino Biological Species Human

Human PYHIN1 ORF Clone(NM_198929.4) - CDCR326372 from Creative biogene Species Human

Human PYHIN1 ORF Clone (BC020822) - CDCS417169 from Creative biogene Species Human Accession Q6K0P9

Human PYHIN1 ORF Clone (BC139741) - CDCS417170 from Creative biogene Species Human Accession Q6K0P9

Human PYHIN1 ORF clone (BC139741) - CDCB157959 from Creative biogene Species Human

Human PYHIN1 Gene cDNA Clone - orb144945 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human PYHIN1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG15657-ACR from Sino Biological Species Human

Human PYHIN1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG15657-ANR from Sino Biological Species Human

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