PRKD2

Gene Symbol	PRKD2
Entrez Gene	25865
Alt Symbol	HSPC187, PKD2, nPKC-D2
Species	Human
Gene Type	protein-coding
Description	protein kinase D2
Other Description	serine/threonine-protein kinase D2
Swissprots	Q9P0T6 Q9Y3X8 Q8NCK8 Q9BZL6 Q8TB08 M0R2R2
Accessions	CAF86729 EAW57441 Q9BZL6 AF151021 AAF36107 AF309082 AAK01149 AK074673 BAC11127 AK075266 BAC11508 AK092896 AK095884 BAG53158 AK300339 BAG62084 AK303629 BAG64637 AL050147 CAB43292 BC015472 AAH15472 BC025307 BC156073 AAI56074 BC156946 AAI56947 DA475821 XM_005258716 XP_005258773 NM_001079880 NP_001073349 NM_001079881 NP_001073350 NM_001079882 NP_001073351 NM_016457 NP_057541
Function	Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress- induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. In response to oxidative stress, is phosphorylated at Tyr-438 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B. In response to the activation of the gastrin r
Subcellular Location	Cytoplasm. Cell membrane {ECO:0000250}. Nucleus. Golgi apparatus, trans-Golgi network. Note=Translocation to the cell membrane is required for kinase activation (By similarity). Accumulates in the nucleus upon CK1-mediated phosphorylation after activation of G-protein-coupled receptors. Nuclear accumulation is regulated by blocking nuclear export of active PRKD2 rather than by increasing import. {ECO:0000250}.
Tissue Specificity	Widely expressed.
Top Pathways	Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat Phospho-PRKD2 / PKD2 (Ser876) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1308 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate

Mouse/Human/Rat PRKD2 / PKD2 ELISA Kit (Cell-Based ELISA) - LS-F2256 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

Protein Kinase D2 NELISA Kit, PKD2, Human, ELISA Kit - E-EL-H1186 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Polycystin-2, PKD2, Human, ELISA Kit - E14978h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 0.312-20 ng/mL

Protein Kinase D2, PKD2, Mouse, ELISA Kit - E-EL-M0981 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protein Kinase D2, PKD2, Rat, ELISA Kit - E-EL-R0817 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protein Kinase D2 NELISA Kit, PKD2, Rabbit, ELISA Kit - E-EL-RB0323 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protein Kinase D2 NELISA Kit, PKD2, Chicken, ELISA Kit - E-EL-Ch0889 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Protein Kinase D2, PKD2, Porcine, ELISA Kit - E-EL-P0630 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Protein Kinase D2 NELISA Kit, PKD2, Guinea Pig, ELISA Kit - E-EL-GP0348 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Protein Kinase D2, PKD2, Monkey, ELISA Kit - E-EL-MK0369 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

PKD2 Colorimetric Cell-Based ELISA Kit - CB5571 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

PKD2 (Phospho-Ser876) Colorimetric Cell-Based ELISA Kit - CBP1313 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human PKD2(Protein Kinase D2) ELISA Kit - E-EL-H1186 from Elabscience Category ELISA Kit Sensitivity 0.94 ng/mL Range 1.56—100 ng/mL

protein kinase D2, ELISA Kit - MBS9320791 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human PKD2(Protein Kinase D2) ELISA Kit - E-EL-H1186 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.94 ng/mLng/mL Range 1.56~100 ng/mL

PKD2 ELISA Kit - DEIA-XYA1473 from Creative Diagnostics Category ELISA Kit

PKD2 (Phospho-Ser876) ELISA Kit - DEIA-XYA1474 from Creative Diagnostics Category ELISA Kit

PKD2 - EKH3388 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.312-20ng/ml

Human PKD2 ELISA Kit - E029472 from Biobool Category ELISA Kit

Human PRKD2 ELISA Kit - E031627 from Biobool Category ELISA Kit

anti-Polycystin 2 / PKD2 antibody - ARG65025 from Arigo Biolaboratories Category ELISA Kit

PRKD2 ELISA Kit (Human) (OKEI00202) - OKEI00202 from Aviva Systems Biology Category ELISA Kit Sensitivity 0.938 ng/mL Range 1.563 - 100 ng/mL

Human PKD2 (Protein Kinase D2) ELISA Kit - EKE60732 from Biomatik Category ELISA Kit Prices $609.00 Sizes 96 tests Sensitivity 0.94 ng/mL Range 1.56-100 ng/mL

PKD2 Colorimetric Cell-Based ELISA Kit - EKA50491 from Biomatik Category ELISA Kit Prices $399.00 Sizes 96 tests Sensitivity At least 5000 cells/well Range Qualitative

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