PRKD2

Gene Symbol	PRKD2
Entrez Gene	25865
Alt Symbol	HSPC187, PKD2, nPKC-D2
Species	Human
Gene Type	protein-coding
Description	protein kinase D2
Other Description	serine/threonine-protein kinase D2
Swissprots	Q9P0T6 Q9Y3X8 Q8NCK8 Q9BZL6 Q8TB08 M0R2R2
Accessions	CAF86729 EAW57441 Q9BZL6 AF151021 AAF36107 AF309082 AAK01149 AK074673 BAC11127 AK075266 BAC11508 AK092896 AK095884 BAG53158 AK300339 BAG62084 AK303629 BAG64637 AL050147 CAB43292 BC015472 AAH15472 BC025307 BC156073 AAI56074 BC156946 AAI56947 DA475821 XM_005258716 XP_005258773 NM_001079880 NP_001073349 NM_001079881 NP_001073350 NM_001079882 NP_001073351 NM_016457 NP_057541
Function	Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress- induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. In response to oxidative stress, is phosphorylated at Tyr-438 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B. In response to the activation of the gastrin r
Subcellular Location	Cytoplasm. Cell membrane {ECO:0000250}. Nucleus. Golgi apparatus, trans-Golgi network. Note=Translocation to the cell membrane is required for kinase activation (By similarity). Accumulates in the nucleus upon CK1-mediated phosphorylation after activation of G-protein-coupled receptors. Nuclear accumulation is regulated by blocking nuclear export of active PRKD2 rather than by increasing import. {ECO:0000250}.
Tissue Specificity	Widely expressed.
Top Pathways	Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PRKD2-Over-expression-Lysate - LY10355a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

PR2 293T Cell Transient Overexpression Lysate(Denatured) - H00025865-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

PRKD2 overexpression lysate - LY402555 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

PRKD2 overexpression lysate - LY421574 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

PRKD2 overexpression lysate - LY421575 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

PRKD2 overexpression lysate - LY425905 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

PRKD2 overexpression lysate - LY425906 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

PRKD2 293 Cell Lysate - 402236 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

Protein Kinase D2 Overexpression Lysate (Denatured) - H00025865-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Protein Kinase D2 Overexpression Lysate (Native) - NBP2-09273 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Protein Kinase D2 Overexpression Lysate (Native) - NBP2-09272 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Protein Kinase D2 Overexpression Lysate (Native) - NBL1-14780 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

PRKD2 Over-expression Lysate Product - GWB-65F1B6 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Human PRKD2 / PKD2 Insect Cell Lysate (WB positive control) - 11671-H20BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Protein Kinase D2 Overexpression Lysate (Native) - NBP2-08484 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Protein Kinase D2 Overexpression Lysate (Native) - NBP2-08483 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Human PRKD2 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb174986 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human PRKD2 Knockdown Stable Cell Line - CSC-DC012408 from Creative biogene Category Cell Line Species Human

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