Gene Symbol | PRKD2 |
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Entrez Gene | 25865 |
Alt Symbol | HSPC187, PKD2, nPKC-D2 |
Species | Human |
Gene Type | protein-coding |
Description | protein kinase D2 |
Other Description | serine/threonine-protein kinase D2 |
Swissprots | Q9P0T6 Q9Y3X8 Q8NCK8 Q9BZL6 Q8TB08 M0R2R2 |
Accessions | CAF86729 EAW57441 Q9BZL6 AF151021 AAF36107 AF309082 AAK01149 AK074673 BAC11127 AK075266 BAC11508 AK092896 AK095884 BAG53158 AK300339 BAG62084 AK303629 BAG64637 AL050147 CAB43292 BC015472 AAH15472 BC025307 BC156073 AAI56074 BC156946 AAI56947 DA475821 XM_005258716 XP_005258773 NM_001079880 NP_001073349 NM_001079881 NP_001073350 NM_001079882 NP_001073351 NM_016457 NP_057541 |
Function | Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress- induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. In response to oxidative stress, is phosphorylated at Tyr-438 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B. In response to the activation of the gastrin r |
Subcellular Location | Cytoplasm. Cell membrane {ECO:0000250}. Nucleus. Golgi apparatus, trans-Golgi network. Note=Translocation to the cell membrane is required for kinase activation (By similarity). Accumulates in the nucleus upon CK1-mediated phosphorylation after activation of G-protein-coupled receptors. Nuclear accumulation is regulated by blocking nuclear export of active PRKD2 rather than by increasing import. {ECO:0000250}. |
Tissue Specificity | Widely expressed. |
Top Pathways | Rap1 signaling pathway |
PKD2 (D1A7) Rabbit mAb - 8188 from Cell Signaling Technology
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PKD2 (H-6) - sc-374213 from Santa Cruz Biotechnology
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PKD2 (F-2) - sc-374344 from Santa Cruz Biotechnology
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PKD2 (C-19) - sc-74838 from Santa Cruz Biotechnology
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PKD2 (E-20) - sc-74839 from Santa Cruz Biotechnology
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PKD2 (431.2) - sc-100415 from Santa Cruz Biotechnology
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Anti-Protein Kinase D2 (phospho S876) antibody - ab59417 from Abcam
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Anti-Protein Kinase D2 (phospho S876) antibody [EP1496Y] - ab51251 from Abcam
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Anti-Protein Kinase D2 antibody - ab7281 from Abcam
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Anti-Protein Kinase D2 antibody - ab57114 from Abcam
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Anti-Protein Kinase D2 antibody - ab118639 from Abcam
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Anti-Protein Kinase D2 antibody - ab59372 from Abcam
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Anti-Protein Kinase D2 antibody - ab103559 from Abcam
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Anti-Protein Kinase D2 antibody [2E4] - ab117718 from Abcam
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Anti-Protein Kinase D2 antibody [3A1] - ab118987 from Abcam
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Anti-Protein Kinase D2 antibody [EP1495Y] - ab51250 from Abcam
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Anti-PRKD2 / PKD2 Antibody (C-Terminus) - LS-C286784 from LifeSpan Bioscience
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Anti-PRKD2 / PKD2 Antibody (aa621-832) - LS-C296118 from LifeSpan Bioscience
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Anti-PRKD2 / PKD2 Antibody (clone 2E4) IHC-plus⢠- LS-B5453 from LifeSpan Bioscience
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Anti-PRKD2 / PKD2 Antibody (C-Terminus) - LS-C287009 from LifeSpan Bioscience
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Anti-PRKD2 / PKD2 Antibody (clone 2E2) - LS-C115567 from LifeSpan Bioscience
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Anti-PRKD2 / PKD2 Antibody (clone 3A1) - LS-C115601 from LifeSpan Bioscience
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Anti-PRKD2 / PKD2 Antibody (aa829-878) IHC-plus⢠- LS-B5654 from LifeSpan Bioscience
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Anti-PRKD2 / PKD2 Antibody (clone 3F7) - LS-C115588 from LifeSpan Bioscience
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Anti-PRKD2 / PKD2 Antibody (clone 5A3) - LS-C115589 from LifeSpan Bioscience
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