PRKD2

Gene Symbol PRKD2
Entrez Gene 25865
Alt Symbol HSPC187, PKD2, nPKC-D2
Species Human
Gene Type protein-coding
Description protein kinase D2
Other Description serine/threonine-protein kinase D2
Swissprots Q9P0T6 Q9Y3X8 Q8NCK8 Q9BZL6 Q8TB08 M0R2R2
Accessions CAF86729 EAW57441 Q9BZL6 AF151021 AAF36107 AF309082 AAK01149 AK074673 BAC11127 AK075266 BAC11508 AK092896 AK095884 BAG53158 AK300339 BAG62084 AK303629 BAG64637 AL050147 CAB43292 BC015472 AAH15472 BC025307 BC156073 AAI56074 BC156946 AAI56947 DA475821 XM_005258716 XP_005258773 NM_001079880 NP_001073349 NM_001079881 NP_001073350 NM_001079882 NP_001073351 NM_016457 NP_057541
Function Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress- induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. In response to oxidative stress, is phosphorylated at Tyr-438 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B. In response to the activation of the gastrin r
Subcellular Location Cytoplasm. Cell membrane {ECO:0000250}. Nucleus. Golgi apparatus, trans-Golgi network. Note=Translocation to the cell membrane is required for kinase activation (By similarity). Accumulates in the nucleus upon CK1-mediated phosphorylation after activation of G-protein-coupled receptors. Nuclear accumulation is regulated by blocking nuclear export of active PRKD2 rather than by increasing import. {ECO:0000250}.
Tissue Specificity Widely expressed.
Top Pathways Rap1 signaling pathway

Human PRKD2 gene - orb92778 from Biorbyt

Prices $366.00
Sizes 10 μg
Species Human

Human PRKD2 cDNA clone(NM_016457.4) - CDFG000315 from Creative Biomart

Species Human
Accession NM_016457.4

Human PRKD2 cDNA clone(NM_001079880.1) - CDFH015143 from Creative Biomart

Species Human
Accession NM_001079880.1

Human PRKD2 cDNA clone(NM_001079882.1) - CDFH015144 from Creative Biomart

Species Human
Accession NM_001079882.1

Human PRKD2 cDNA clone(NM_001079881.1) - CDFH015145 from Creative Biomart

Species Human
Accession NM_001079881.1

Human PRKD2 cDNA clone(NM_001079882.1) - CDFH015146 from Creative Biomart

Species Human
Accession NM_001079882.1

Human PRKD2 ORF clone(NM_016457.4) - CDCL185834 from Creative Biomart

Species Human
Accession NM_016457.4

Human PRKD2 ORF clone(NM_016457.4) - CDCH395250 from Creative Biomart

Species Human
Accession NM_016457.4

Human PRKD2 ORF Clone(NM_016457.4) - CDCL172666 from Creative Biomart

Species Human
Accession NM_016457.4

Human PRKD2 ORF Clone(NM_001079880.1) - CDCL172667 from Creative Biomart

Species Human
Accession NM_001079880.1

Human PRKD2 ORF Clone(NM_001079880.1) - CDCR345489 from Creative Biomart

Species Human
Accession NM_001079880.1

Human PRKD2 ORF Clone(NM_001079880.1) - CDCR345490 from Creative Biomart

Species Human
Accession NM_001079880.1

Human PRKD2 ORF Clone(NM_001079881.1) - CDCR345491 from Creative Biomart

Species Human
Accession NM_001079881.1

Human PRKD2 ORF Clone(NM_001079881.1) - CDCR345492 from Creative Biomart

Species Human
Accession NM_001079881.1

Human PRKD2 ORF Clone(NM_001079882.1) - CDCR345493 from Creative Biomart

Species Human
Accession NM_001079882.1

Human PRKD2 ORF Clone(NM_001079882.1) - CDCR345494 from Creative Biomart

Species Human
Accession NM_001079882.1
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