PRKD2

Gene Symbol	PRKD2
Entrez Gene	25865
Alt Symbol	HSPC187, PKD2, nPKC-D2
Species	Human
Gene Type	protein-coding
Description	protein kinase D2
Other Description	serine/threonine-protein kinase D2
Swissprots	Q9P0T6 Q9Y3X8 Q8NCK8 Q9BZL6 Q8TB08 M0R2R2
Accessions	CAF86729 EAW57441 Q9BZL6 AF151021 AAF36107 AF309082 AAK01149 AK074673 BAC11127 AK075266 BAC11508 AK092896 AK095884 BAG53158 AK300339 BAG62084 AK303629 BAG64637 AL050147 CAB43292 BC015472 AAH15472 BC025307 BC156073 AAI56074 BC156946 AAI56947 DA475821 XM_005258716 XP_005258773 NM_001079880 NP_001073349 NM_001079881 NP_001073350 NM_001079882 NP_001073351 NM_016457 NP_057541
Function	Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress- induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. In response to oxidative stress, is phosphorylated at Tyr-438 by ABL1, which leads to the activation of PRKD2 without increasing its catalytic activity, and mediates activation of NF-kappa-B. In response to the activation of the gastrin r
Subcellular Location	Cytoplasm. Cell membrane {ECO:0000250}. Nucleus. Golgi apparatus, trans-Golgi network. Note=Translocation to the cell membrane is required for kinase activation (By similarity). Accumulates in the nucleus upon CK1-mediated phosphorylation after activation of G-protein-coupled receptors. Nuclear accumulation is regulated by blocking nuclear export of active PRKD2 rather than by increasing import. {ECO:0000250}.
Tissue Specificity	Widely expressed.
Top Pathways	Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Protein Kinase D2 (mutated G870 E) full length protein - ab167923 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human Protein Kinase D2 full length protein - ab60875 from Abcam Category Protein Prices $294.00, $1,845.00 Sizes 10 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Human Protein Kinase D2 full length protein - ab153249 from Abcam Category Protein Source Wheat germ Species Human

Human Protein Kinase D2 protein fragment - ab153250 from Abcam Category Protein Source Wheat germ Species Human

PKD2 / Polycystin 2 Antibody Blocking Peptide - LS-E3621 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PKD2 / Polycystin 2 Antibody Blocking Peptide - LS-E27134 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKD2 / PKD2 Antibody Blocking Peptide - LS-E29273 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human Protein Kinase D2 Protein - H00025865-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Protein Kinase D2 Protein - H00025865-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Polycystin 2 Protein - H00005311-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Protein Kinase D2 Recombinant Protein - P4195 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

Protein Kinase D2 Recombinant Protein - P3907 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

Recombinant Protein Kinase D2 Protein - NBP1-99467 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

Polycystin 2 Peptide - P2917 from Novus Biologicals Category Peptide Species Human

PKD2-Antibody-C-term-Blocking-Peptide - BP7934a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human PRKD2 His GST tag protein - orb83998 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Insect Species Human

PKD2 protein - 30R-2826 from Fitzgerald Category Protein Prices $250.00 Sizes 5 µg Source Sf-9 insect cells Species Human

Human Protein Kinase D2 Protein - abx068756 from Abbexa Category Protein Source E.coli Species Human

PRKD2 / PKD2 - H00025865-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PRKD2 / PKD2 - H00025865-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PRKD2 / PKD2 - H00025865-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PRKD2 / PKD2 - H00025865-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PRKD2 / PKD2 - P3907 from Acris Antibodies Category Protein Prices $1,230.00 Sizes 5 µg Species Human

PRKD2 fusion protein - Ag2192 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

PRKD2 fusion protein - Ag24668 from Proteintech Group Category Protein Prices $199.00 Sizes 50 Source E. coli -derived, PET28a Species Human

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