| Gene Symbol |
SLC39A4
|
| Entrez Gene |
55630
|
| Alt Symbol |
AEZ, AWMS2, ZIP4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 39 (zinc transporter), member 4
|
| Other Description |
zinc transporter ZIP4|zrt- and Irt-like protein 4
|
| Swissprots |
Q6P5W5 Q9NXC4 Q7L5S5 Q9H6T8
|
| Accessions |
CAH05339 CAH05356 EAW82101 EAW82102 EAW82103 EAW82104 EAW82105 Q6P5W5 AK000334 BAA91091 AK000489 BAA91200 AK000695 AK025537 BAB15164 AK056900 AK290563 BAF83252 BC001688 AAH01688 BC033807 BC062625 AAH62625 BE798833 BI765535 DA837547 DA915781 DC361959 XM_006716599 XP_006716662 XM_011517153 XP_011515455 NM_001280557 NP_001267486 NM_017767 NP_060237 NM_130849 NP_570901
|
| Function |
Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:14612438}; Multi-pass membrane protein {ECO:0000269|PubMed:14612438}. Recycling endosome membrane {ECO:0000269|PubMed:14612438}; Multi- pass membrane protein {ECO:0000269|PubMed:14612438}. Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability.
|
| Tissue Specificity |
Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum. {ECO:0000269|PubMed:12032886, ECO:0000269|PubMed:12068297}.
|
| Top Pathways |
Mineral absorption
|
![Western Blot: SLC39A4/ZIP4 Overexpression Lysate (Adult Normal) [NBL1-16147] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SLC39A4/ZIP4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10553_SLC39A4-ZIP4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16147-img0002.jpg)