Gene Symbol | SLC39A4 |
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Entrez Gene | 55630 |
Alt Symbol | AEZ, AWMS2, ZIP4 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 39 (zinc transporter), member 4 |
Other Description | zinc transporter ZIP4|zrt- and Irt-like protein 4 |
Swissprots | Q6P5W5 Q9NXC4 Q7L5S5 Q9H6T8 |
Accessions | CAH05339 CAH05356 EAW82101 EAW82102 EAW82103 EAW82104 EAW82105 Q6P5W5 AK000334 BAA91091 AK000489 BAA91200 AK000695 AK025537 BAB15164 AK056900 AK290563 BAF83252 BC001688 AAH01688 BC033807 BC062625 AAH62625 BE798833 BI765535 DA837547 DA915781 DC361959 XM_006716599 XP_006716662 XM_011517153 XP_011515455 NM_001280557 NP_001267486 NM_017767 NP_060237 NM_130849 NP_570901 |
Function | Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:14612438}; Multi-pass membrane protein {ECO:0000269|PubMed:14612438}. Recycling endosome membrane {ECO:0000269|PubMed:14612438}; Multi- pass membrane protein {ECO:0000269|PubMed:14612438}. Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability. |
Tissue Specificity | Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum. {ECO:0000269|PubMed:12032886, ECO:0000269|PubMed:12068297}. |
Top Pathways | Mineral absorption |
Mouse SLC39A4 (NP_082340) VersaClone cDNA - RDC0789 from R&D Systems
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SLC39A4 cDNA (ANA11091) - ANA11091 from Aviva Systems Biology
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SLC39A4 - MBS1276540 from MyBioSource
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Human SLC39A4 cDNA clone(NM_130849.2) - CDFG007641 from Creative Biomart
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Human SLC39A4 ORF Clone(NM_130849.2) - CDCR315874 from Creative Biomart
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Human SLC39A4 ORF Clone(NM_130849.2) - CDCR315875 from Creative Biomart
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Human SLC39A4 ORF Clone(NM_017767.2) - CDCL176080 from Creative Biomart
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Human SLC39A4 ORF Clone(NM_017767.2) - CDCL176081 from Creative Biomart
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human SLC39A4 ORF clone - CDCH082362 from Creative Biomart
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human SLC39A4 ORF clone - CDCH082363 from Creative Biomart
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human SLC39A4 ORF clone - CDCH082364 from Creative Biomart
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human SLC39A4 ORF clone - CDCH082365 from Creative Biomart
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human SLC39A4 ORF clone - CDCH082366 from Creative Biomart
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human SLC39A4 ORF clone - CDCH082367 from Creative Biomart
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human SLC39A4 ORF clone - CDCH082368 from Creative Biomart
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human SLC39A4 ORF clone - CDCH082369 from Creative Biomart
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human SLC39A4 ORF clone (NM_017767.2) - CDCH082362 from Creative biogene
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human SLC39A4 ORF clone (NM_130849.2) - CDCH082364 from Creative biogene
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Human SLC39A4 ORF Clone (BC062625) - CDCS419565 from Creative biogene
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Human SLC39A4 cDNA Clone(NM_130849.2) - CDFG007641 from Creative biogene
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