Gene Symbol | SLC39A4 |
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Entrez Gene | 55630 |
Alt Symbol | AEZ, AWMS2, ZIP4 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 39 (zinc transporter), member 4 |
Other Description | zinc transporter ZIP4|zrt- and Irt-like protein 4 |
Swissprots | Q6P5W5 Q9NXC4 Q7L5S5 Q9H6T8 |
Accessions | CAH05339 CAH05356 EAW82101 EAW82102 EAW82103 EAW82104 EAW82105 Q6P5W5 AK000334 BAA91091 AK000489 BAA91200 AK000695 AK025537 BAB15164 AK056900 AK290563 BAF83252 BC001688 AAH01688 BC033807 BC062625 AAH62625 BE798833 BI765535 DA837547 DA915781 DC361959 XM_006716599 XP_006716662 XM_011517153 XP_011515455 NM_001280557 NP_001267486 NM_017767 NP_060237 NM_130849 NP_570901 |
Function | Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:14612438}; Multi-pass membrane protein {ECO:0000269|PubMed:14612438}. Recycling endosome membrane {ECO:0000269|PubMed:14612438}; Multi- pass membrane protein {ECO:0000269|PubMed:14612438}. Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability. |
Tissue Specificity | Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum. {ECO:0000269|PubMed:12032886, ECO:0000269|PubMed:12068297}. |
Top Pathways | Mineral absorption |
Anti-SLC39A4 antibody - ab117550 from Abcam
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Anti-SLC39A4 antibody - ab90076 from Abcam
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Anti-SLC39A4 antibody - ab92990 from Abcam
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Anti-SLC39A4 / ZIP4 Antibody (aa460-472) - LS-C112784 from LifeSpan Bioscience
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Anti-SLC39A4 / ZIP4 Antibody (aa431-480) - LS-C291432 from LifeSpan Bioscience
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Anti-SLC39A4 / ZIP4 Antibody (aa359-408) - LS-C110842 from LifeSpan Bioscience
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Anti-SLC39A4 / ZIP4 Antibody (N-Terminus) - LS-C80637 from LifeSpan Bioscience
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Anti-SLC39A4 / ZIP4 Antibody (aa38-87) - LS-C80626 from LifeSpan Bioscience
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Anti-SLC39A4 / ZIP4 Antibody - LS-C335353 from LifeSpan Bioscience
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SLC39A4/ZIP4 Antibody - NBP1-59789 from Novus Biologicals
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SLC39A4/ZIP4 Antibody - NBP1-89225 from Novus Biologicals
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SLC39A4/ZIP4 Antibody - NBP1-36988 from Novus Biologicals
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Anti-SLC39A4 (ab2) antibody produced in rabbit - SAB2102212 from Sigma-Aldrich
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Anti-SLC39A4 (ab1) antibody produced in rabbit - SAB2102211 from Sigma-Aldrich
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Anti-SLC39A4 antibody produced in rabbit - SAB2103808 from Sigma-Aldrich
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Anti-SLC39A4 antibody produced in rabbit - HPA031507 from Sigma-Aldrich
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Anti-ZIP4 antibody produced in rabbit - SAB3500595 from Sigma-Aldrich
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SLC39A4 antibody - N-terminal region (ARP43975_P050) - ARP43975_P050 from Aviva Systems Biology
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SLC39A4 antibody - middle region (ARP43976_P050) - ARP43976_P050 from Aviva Systems Biology
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SLC39A4 antibody - N-terminal region (ARP44090_P050) - ARP44090_P050 from Aviva Systems Biology
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SLC39A4-Antibody-internal-region - AF2852a from Abgent, a WuXi AppTec company
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Mouse SLC39A4 Antibody - AF7315 from R&D Systems
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Mouse SLC39A4 Affinity Purified Polyclonal Ab, Goat IgG - AF7315-SP from R&D Systems
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SLC39A4 Antibody (OAAF04482) - OAAF04482 from Aviva Systems Biology
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ZIP4 antibody - orb75533 from Biorbyt
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