TNFSF14

Gene Symbol TNFSF14
Entrez Gene 8740
Alt Symbol CD258, HVEML, LIGHT, LTg, TR2
Species Human
Gene Type protein-coding
Description tumor necrosis factor (ligand) superfamily, member 14
Other Description delta transmembrane LIGHT|herpes virus entry mediator ligand|herpesvirus entry mediator A|herpesvirus entry mediator ligand|herpesvirus entry mediator-ligand|ligand for herpesvirus entry mediator|tumor necrosis factor ligand superfamily member 14|tumor necrosis factor receptor-like 2|tumor necrosis factor superfamily member LIGHT
Swissprots A8K7M2 O43557 Q6FHA1 O75476 Q96LD2 C9J5H4 Q8WVF8
Accessions AAN34658 CAL00173 CBX47488 EAW69072 EAW69073 O43557 AF036581 AAC39563 AF064090 AAC25169 AK026704 AK292037 BAF84726 AY028261 AAK26160 AY358812 AAQ89171 BC018058 BC152848 AAI52849 CR541854 CAG46652 CR541871 CAG46669 XM_005259670 XP_005259727 XM_011528398 XP_011526700 XR_936212 NM_003807 NP_003798 NM_172014 NP_742011
Function Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
Subcellular Location Isoform 2: Cytoplasm.
Tissue Specificity Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.
Top Pathways Cytokine-cytokine receptor interaction, Herpes simplex infection

LIGHT (C-20) - sc-7767 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LIGHT (C-20): sc-7767. Western blot analysis of truncated mouse recombinant LIGHT.

LIGHT (P-18) - sc-22707 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

LIGHT (FL-240) - sc-28880 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
LIGHT (FL-240): sc-28880. Immunofluorescence staining of normal mouse liver frozen section showing cytoplasmic and extracellular staining.

LIGHT (E-13) - sc-34117 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

LIGHT (A-20) - sc-34119 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

LIGHT (I-12) - sc-34120 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

LIGHT (N-19) - sc-7768 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LIGHT (N-19): sc-7768. Immunoperoxidase staining of formalin fixed, paraffin-embedded human spleen tissue showing cytoplasmic staining of subset of cells in red pulp.

Anti-LIGHT antibody - ab57901 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
LIGHT antibody (ab57901) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human spleen.

Anti-LIGHT antibody - ab201094 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-LIGHT antibody (ab201094)Lane 1 : Hela whole cell lysateLane 2 : Raw264.7 whole cell lysate

Anti-LIGHT antibody - ab90133 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-LIGHT antibody (ab90133) at 1 µg/ml (in 5% skim milk / PBS buffer) + 721_B cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-LIGHT antibody - ab123279 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-LIGHT antibody (ab123279) at 1/100 dilution + A549 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-LIGHT antibody - ab18881 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LIGHT antibody [122] - ab140239 from Abcam

Prices $370.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone 122

Anti-LIGHT antibody [7-3 (7)], prediluted (Allophycocyanin) - ab155363 from Abcam

Prices $222.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone 7-3 (7)
Flow cytometric analysis of normal Human peripheral blood cells with Anti-Human CD8a PE and mouse IgG1 kappa Isotype Control APC (left) or 5 µl (0.25 µg) of ab155363 (right). Total viable cells were used for analysis.

Anti-LIGHT antibody [MM0456-8C34] - ab89793 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0456-8C34

Anti-TNFSF14 / LIGHT Antibody (aa51-100) - LS-C118682 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of HeLa cells, using TNF14 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-TNFSF14 / LIGHT Antibody (aa65-94, FITC) - LS-C271892 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TNFSF14 / LIGHT Antibody (aa65-94, Azide-free, HRP) - LS-C271895 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TNFSF14 / LIGHT Antibody (C-Terminus) - LS-C112285 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TNFSF14 / LIGHT antibody LS-C112285 Western blot of 721_B Cell lysate. Antibody concentration 1 ug/ml.

Anti-TNFSF14 / LIGHT Antibody (aa65-94, PE) - LS-C271896 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TNFSF14 / LIGHT Antibody (clone 7-3 (7), APC) - LS-C107268 from LifeSpan Bioscience

Prices $265.00, $395.00
Sizes 25 tst, 100 tst
Host Mouse
Clonality Monoclonal
Staining of PMA and ionomycin-stimulated normal human peripheral blood cells with PE anti-human CD8a (RPA-T8) (LS-C106562) and 0.25 ug of APC Mouse IgG1, K isotype control (left) or APC anti-human CD258 (7-3) (right). Total viable cells were used for analysis.

Anti-TNFSF14 / LIGHT Antibody (aa62-240, Biotin) - LS-C297074 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TNFSF14 / LIGHT Antibody (aa62-240, Biotin) - LS-C299110 from LifeSpan Bioscience

Prices $405.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-TNFSF14 / LIGHT Antibody (aa58-239, Biotin) - LS-C299313 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TNFSF14 / LIGHT Antibody (aa90-103) - LS-C108144 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
TNFSF14 antibody (1 ug/ml) staining of Human Cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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