| Gene Symbol |
TNFSF14
|
| Entrez Gene |
8740
|
| Alt Symbol |
CD258, HVEML, LIGHT, LTg, TR2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tumor necrosis factor (ligand) superfamily, member 14
|
| Other Description |
delta transmembrane LIGHT|herpes virus entry mediator ligand|herpesvirus entry mediator A|herpesvirus entry mediator ligand|herpesvirus entry mediator-ligand|ligand for herpesvirus entry mediator|tumor necrosis factor ligand superfamily member 14|tumor necrosis factor receptor-like 2|tumor necrosis factor superfamily member LIGHT
|
| Swissprots |
A8K7M2 O43557 Q6FHA1 O75476 Q96LD2 C9J5H4 Q8WVF8
|
| Accessions |
AAN34658 CAL00173 CBX47488 EAW69072 EAW69073 O43557 AF036581 AAC39563 AF064090 AAC25169 AK026704 AK292037 BAF84726 AY028261 AAK26160 AY358812 AAQ89171 BC018058 BC152848 AAI52849 CR541854 CAG46652 CR541871 CAG46669 XM_005259670 XP_005259727 XM_011528398 XP_011526700 XR_936212 NM_003807 NP_003798 NM_172014 NP_742011
|
| Function |
Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
|
| Subcellular Location |
Isoform 2: Cytoplasm.
|
| Tissue Specificity |
Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Herpes simplex infection
|
![Western Blot: TNFSF14 Overexpression Lysate (Adult Normal) [NBP2-07946] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TNFSF14.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8536_TNFSF14%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07946-img0001.jpg)